Publication
Utilização de compostos com atividade antimalárica no controlo de perkinsiose em bivalves
| dc.contributor.author | Cabral, Lília | |
| dc.contributor.author | Dias, Catarina | |
| dc.contributor.author | Leite, Ricardo | |
| dc.contributor.author | Cristiano, Maria De Lurdes | |
| dc.date.accessioned | 2020-07-07T16:03:14Z | |
| dc.date.available | 2020-07-07T16:03:14Z | |
| dc.date.issued | 2019-10 | |
| dc.description.abstract | Outbreaks of protozoan agents such as Perkinsus olseni represent major losses for the shellfish producers, urging the development of measures to contain and decrease these episodes. Antimalarial drugs and selective inhibitors designed to target unique metabolic features of the parasite (metabolisms that are not replicated in the host, such as the folate, and shikimate pathways), have been successfully used in the laboratory to inhibit Perkinsus proliferation. However, due to specificities in Perkinsus species and the surrounding environment, development of drug candidates requires further optimization at the molecular level, to improve pharmacologic properties, as well as development of suitable tests and administration protocols for adequate use. Recent advances and future perspectives on the use endoperoxide-type antimalarials for perkinsosis therapy are presented and discussed. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.issn | 2184-6170 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/14059 | |
| dc.language.iso | por | pt_PT |
| dc.peerreviewed | no | pt_PT |
| dc.publisher | Universidade do Algarve | pt_PT |
| dc.subject | Dieta mediterrânica | |
| dc.title | Utilização de compostos com atividade antimalárica no controlo de perkinsiose em bivalves | pt_PT |
| dc.type | other | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 15 | pt_PT |
| oaire.citation.startPage | 11 | pt_PT |
| oaire.citation.title | UALGoritmo. A ciência trocada por miúdos | pt_PT |
| oaire.citation.volume | 1 | pt_PT |
| person.familyName | Cabral | |
| person.familyName | Leite | |
| person.familyName | Cristiano | |
| person.givenName | Lília | |
| person.givenName | Ricardo | |
| person.givenName | Maria de Lurdes | |
| person.identifier | 447622 | |
| person.identifier.ciencia-id | 3510-24A8-36B6 | |
| person.identifier.ciencia-id | F115-256E-C84D | |
| person.identifier.ciencia-id | E411-6006-5A01 | |
| person.identifier.orcid | 0000-0001-9362-8128 | |
| person.identifier.orcid | 0000-0002-9622-3895 | |
| person.identifier.orcid | 0000-0002-9447-2855 | |
| person.identifier.rid | M-4279-2013 | |
| person.identifier.rid | B-3389-2008 | |
| person.identifier.rid | G-2345-2012 | |
| person.identifier.scopus-author-id | 8362650900 | |
| person.identifier.scopus-author-id | 9238724800 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | other | pt_PT |
| relation.isAuthorOfPublication | 175a6aa3-9993-480b-9663-ed083a17eedf | |
| relation.isAuthorOfPublication | 3fb360e0-a481-486e-96ca-af9f6ecd6eb8 | |
| relation.isAuthorOfPublication | b16751a6-748e-44b0-9c59-058cbd5b2cc3 | |
| relation.isAuthorOfPublication.latestForDiscovery | 3fb360e0-a481-486e-96ca-af9f6ecd6eb8 |
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