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Tissue specific responses to cadmium-based quantum dots in the marine mussel Mytilus galloprovincialis

2015Journal article Restricted access
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dc.contributor.authorLopes Rocha, Thiago
dc.contributor.authorGomes, Tânia
dc.contributor.authorMestre, Nélia
dc.contributor.authorCardoso, Cátia
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-04-22T10:08:26Z
dc.date.available2020-04-22T10:08:26Z
dc.date.issued2015
dc.description.abstractIn recent years, Cd-based quantum dots (QDs) have generated interest from the life sciences community due to their potential applications in nanomedicine, biology and electronics. However, these engineered nanomaterials can be released into the marine environment, where their environmental health hazards remain unclear. This study investigated the tissue-specific responses related to alterations in the antioxidant defense system induced by CdTe QDs, in comparison with its dissolved counterpart, using the marine mussel Mytilus galloprovincialis. Mussels were exposed to CdTe QDs and dissolved Cd for 14 days at 10 μgCd L(-1) and biomarkers of oxidative stress [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidases (total, Se-independent and Se-dependent GPx) and glutathione-S-transferase (GST) activities] were analyzed along with Cd accumulation in the gills and digestive gland of mussels. Results show that both Cd forms changed mussels' antioxidant responses with distinct modes of action (MoA). There were tissue- and time-dependent differences in the biochemical responses to each Cd form, wherein QDs are more pro-oxidant when compared to dissolved Cd. The gills are the main tissue affected by QDs, with effects related to the increase of SOD, GST and GPx activities, while those of dissolved Cd was associated to the increase of CAT activity, Cd accumulation and exposure time. Digestive gland is a main tissue for accumulation of both Cd forms, but changes in antioxidant enzyme activities are smaller than in gills. A multivariate analysis revealed that the antioxidant patterns are tissue dependent, indicating nano-specific effects possibly associated to oxidative stress and changes in redox homeostasis.pt_PT
dc.description.sponsorshipPortuguese Foundation of Science and Technology (FCT) project NANOECOTOX (PTDC/AACAMB/121650/2010) and by the Brazilian Science Without Borders Program (239524/2012-8) of the National Council for Scientific and Technological Development (CNPq)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.aquatox.2015.10.001pt_PT
dc.identifier.issn0166-445X
dc.identifier.urihttp://hdl.handle.net/10400.1/13740
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationNANOECOTOX-Impacts of metal nanoparticles to aquatic ecosystems: from community responses to cellular targets
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectCadmiumpt_PT
dc.subjectCatalasept_PT
dc.subjectDigestive systempt_PT
dc.subjectGillspt_PT
dc.subjectGlutathione peroxidasept_PT
dc.subjectMytiluspt_PT
dc.subjectOxidative stresspt_PT
dc.subjectParticle sizept_PT
dc.subjectQuantum dotspt_PT
dc.subjectReactive oxygen speciespt_PT
dc.subjectSuperoxide dismutasept_PT
dc.subjectTissue distributionpt_PT
dc.subjectWater pollutantspt_PT
dc.subjectChemicalpt_PT
dc.titleTissue specific responses to cadmium-based quantum dots in the marine mussel Mytilus galloprovincialispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNANOECOTOX-Impacts of metal nanoparticles to aquatic ecosystems: from community responses to cellular targets
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projectos de Investigação Científica e Desenvolvimento Tecnológico em todos os Domínios Científicos - 2010/PTDC%2FAAC-AMB%2F121650%2F2010/PT
oaire.citation.endPage18pt_PT
oaire.citation.startPage10pt_PT
oaire.citation.titleAquatic Toxicologypt_PT
oaire.citation.volume169pt_PT
oaire.fundingStreamConcurso de Projectos de Investigação Científica e Desenvolvimento Tecnológico em todos os Domínios Científicos - 2010
person.familyNameLopes Rocha
person.familyNameGomes
person.familyNameMestre
person.familyNameCardoso
person.familyNameBebianno
person.givenNameThiago
person.givenNameTânia
person.givenNameNélia
person.givenNameCátia
person.givenNameMaria
person.identifier195864
person.identifier.ciencia-idD71D-759D-F6FC
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-0551-6842
person.identifier.orcid0000-0001-6179-4543
person.identifier.orcid0000-0001-6871-9984
person.identifier.orcid0000-0003-3157-9898
person.identifier.orcid0000-0003-1492-8566
person.identifier.ridA-3864-2015
person.identifier.ridC-1943-2009
person.identifier.ridI-9235-2014
person.identifier.scopus-author-id37007842200
person.identifier.scopus-author-id35237689600
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication71dcd70c-3a6a-45f7-bbe7-6b8a5346cc88
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