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Spray-drying of konjac glucomannan to produce microparticles for an application as antitubercular drug carriers

2019-01Journal article Restricted access
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dc.contributor.authorGuerreiro, Filipa
dc.contributor.authorPontes, Jorge Filipe
dc.contributor.authorRosa Da Costa, Ana
dc.contributor.authorGrenha, Ana
dc.date.accessioned2020-04-06T11:00:17Z
dc.date.available2021-01-01T01:30:12Z
dc.date.issued2019-01
dc.description.abstractSpray-drying is proposed in this work as the technique to produce konjac glucomannan microparticles aimed at an application in lung tuberculosis therapy. Microparticles were developed to provide direct lung delivery of an association of two first-line antitubercular drugs, isoniazid and rifabutin, by inhalation. Mannitol or leucine were incorporated as spray-drying excipients to verify their effect on the final properties of drug-loaded konjac glucomannan microparticles. The obtained results indicate that konjac glucomannan is a suitable material for the preparation of inhalable microparticles for antitubercular therapy upon processing by spray-drying. The incorporation of excipients revealed no benefit on the characterised properties. Isoniazid and rifabutin were mostly associated to microparticles with success (efficiencies of 88-104%). However, the presence of mannitol was found to decrease the capacity to associate isoniazid (efficiency of 43%). The excipients further promoted the acceleration of drug release. Moreover, general absence of toxicity was observed for microparticles in Calu-3 and A549 cells, with cell viabilities above 70%. The results of the work suggest that microparticles composed only of KGM display the most appropriate characteristics.pt_PT
dc.description.sponsorshipPEst-OE/QUI/UI4023/2011; SFRH/BD/115628/2016pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.powtec.2018.09.068pt_PT
dc.identifier.issn0032-5910
dc.identifier.urihttp://hdl.handle.net/10400.1/13694
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationFighting TB: Development of microparticulate systems to target alveolar macrophages in tuberculosis therapy
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0032591018307939pt_PT
dc.subjectAntitubercular drugspt_PT
dc.subjectKonjac glucomannan microparticlespt_PT
dc.subjectPulmonary deliverypt_PT
dc.subjectSpray-dryingpt_PT
dc.titleSpray-drying of konjac glucomannan to produce microparticles for an application as antitubercular drug carrierspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFighting TB: Development of microparticulate systems to target alveolar macrophages in tuberculosis therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F0094%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.citation.endPage252pt_PT
oaire.citation.startPage246pt_PT
oaire.citation.titlePowder Technologypt_PT
oaire.citation.volume342pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameGuerreiro
person.familyNamePontes
person.familyNameRosa da Costa
person.familyNameGrenha
person.givenNameFilipa
person.givenNameJorge Filipe
person.givenNameAna M
person.givenNameAna
person.identifier305029
person.identifier.ciencia-idBF1D-7EFA-19BC
person.identifier.ciencia-idCB16-5CBD-8B89
person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.ciencia-id091C-0D58-7225
person.identifier.orcid0000-0001-6224-1553
person.identifier.orcid0000-0002-6447-0242
person.identifier.orcid0000-0003-0225-9537
person.identifier.orcid0000-0002-2136-1396
person.identifier.ridE-2165-2012
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id57195033461
person.identifier.scopus-author-id53986075100
person.identifier.scopus-author-id8607930100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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