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Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)

2021-04Journal article Open Access
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dc.contributor.authorAraújo, Nuna
dc.contributor.authorViegas, Carla
dc.contributor.authorPontes, Jorge Filipe
dc.contributor.authorMarreiros, Catarina
dc.contributor.authorRaimundo, Pedro
dc.contributor.authorMacedo, Anjos L.
dc.contributor.authorAlves de Matos, António
dc.contributor.authorGrenha, Ana
dc.contributor.authorVermeer, Cees
dc.contributor.authorSimes, Dina
dc.date.accessioned2021-10-22T14:33:54Z
dc.date.available2021-10-22T14:33:54Z
dc.date.issued2021-04
dc.description.abstractGla rich protein (GRP) is a vitamin K dependent protein, shown to function as an inhibitor of pathological calcification and as an anti-inflammatory agent, with potential therapeutic use for age-related diseases such as osteoarthritis (OA) [1,2]. OA is a leading cause of disability and morbidity in the older population and constitutes a major world wide challenge for our health system. Presently, there are no drugs approved that can prevent, stop, or even restrain progression of OA. GRP has been shown to be able to lower inflammation and mineralisation processes in the articular tissue. Chitosan/tripolyphosphate (TPP) nanoparticles were selected for this study due to their biocompatibility, biodegradability and capacity to overcome the problem of low solubility of GRP in physiological conditions. This study aims to produce and characterise chitosan/TPP nanoparticles as GRP-delivery vehicles and test its anti-inflammatory potential in human macrophages.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/07853890.2021.1896900pt_PT
dc.identifier.eissn1365-2060
dc.identifier.urihttp://hdl.handle.net/10400.1/17248
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationApplied Molecular Biosciences Unit
dc.relationNot Available
dc.relationAlgarve Centre for Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleNanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)pt_PT
dc.title.alternativeNanoencapsulação como uma nova abordagem de entrega para aplicações terapêuticas de proteína rica em gla (GRP)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleNot Available
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL 57%2F2016%2FCP1361%2FCT0006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.endPageS24pt_PT
oaire.citation.issuesup1pt_PT
oaire.citation.startPageS23pt_PT
oaire.citation.titleAnnals of Medicinept_PT
oaire.citation.volume53pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamDL 57/2016
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAraújo
person.familyNameViegas
person.familyNamePontes
person.familyNameMARREIROS
person.familyNameFernandes Oliveira Raimundo
person.familyNameGrenha
person.familyNameSimes
person.givenNameNuna
person.givenNameCarla
person.givenNameJorge Filipe
person.givenNameCATARINA
person.givenNamePedro
person.givenNameAna
person.givenNameDina
person.identifier.ciencia-idCD1B-789D-642A
person.identifier.ciencia-idC414-F596-EEC6
person.identifier.ciencia-idCB16-5CBD-8B89
person.identifier.ciencia-idB116-E70E-EB2A
person.identifier.ciencia-idA21C-0F18-8002
person.identifier.ciencia-id091C-0D58-7225
person.identifier.orcid0000-0002-5765-3665
person.identifier.orcid0000-0002-6447-0242
person.identifier.orcid0000-0002-2136-1396
person.identifier.orcid0000-0002-5145-4753
person.identifier.ridN-6695-2014
person.identifier.ridH-1392-2017
person.identifier.ridN-2789-2014
person.identifier.scopus-author-id8656310300
person.identifier.scopus-author-id57195033461
person.identifier.scopus-author-id8607930100
person.identifier.scopus-author-id7201884723
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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