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Protective properties of the edible halophyte Carpobrotus edulis (L.) N.E.Br. towards neoformed food contaminants-related oxidative stress and genotoxicity

2024-10Journal article Restricted access
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dc.contributor.authorOliveira, Daniela
dc.contributor.authorHayrapetyan, Ruzanna
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorSéverin, Isabelle
dc.contributor.authorCustódio, Luísa
dc.contributor.authorChagnon, Marie-Christine
dc.contributor.authorOliveira, Rui
dc.date.accessioned2024-12-03T09:48:52Z
dc.date.available2024-12-03T09:48:52Z
dc.date.issued2024-10
dc.description.abstractCarpobrotus edulis (L.) N.E.Br. is an edible halophyte native to South Africa, where it has been traditionally consumed as food, revealing its nutritional value, and used in the treatment of human diseases probably due to the accumulation of bioactive compounds such as polyphenols. These compounds have potential to display valuable biological activities that could bring several benefits to the human being, including the mitigation of toxicity induced by food contaminants. Therefore, this study investigated biological activities with healthpromoting potential of a C. edulis ethanol extract (CEE), such as antioxidant, antigenotoxic, and antimutagenic. CEE was shown by LC-DAD-ESI/MSn to be composed of 16 polyphenols. The extract exhibited antioxidant properties by protecting Saccharomyces cerevisiae viability and improving the redox state of HepG2 cells under oxidative stress. Antigenotoxicity of CEE against H2O2-induced oxidative damage was detected in HepG2 and Caco-2 cells by comet assay and subsequently observed in the dominant deletion assay in S. cerevisiae. Antigenotoxicity and antimutagenicity of CEE towards the neoformed contaminant benzo[a]pyrene was found in HepG2 and Caco-2 cells by comet assay and in Salmonella typhimurium using the Ames test, respectively. The disclosed antigenotoxic and antimutagenic properties of C. edulis further advance its potential for application in food and nutraceutical industries for health benefits.eng
dc.description.sponsorshipCOVID/BD/152478/2022; PD/00122/2012; CEECIND/00425/2017; LA/P/0007/2020
dc.identifier.doi10.1016/j.fbio.2024.104447
dc.identifier.issn2212-4292
dc.identifier.urihttp://hdl.handle.net/10400.1/26378
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationValorisation of halophyte plants present in Portuguese territory through the investigation of their protective effects against food toxicants - Study of bioactivities of plant-based products to attenuate the effects of food toxicants
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationExploring salt tolerant plants as sources of innovative food additives
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relation.ispartofFood Bioscience
dc.rights.uriN/A
dc.subjectSour fig
dc.subjectHalophyte
dc.subjectAntimutagenic
dc.subjectAntigenotoxic
dc.subjectBenzo[a]pyrene
dc.subjectCarpobrotus edulis (L.) N.E.Br
dc.titleProtective properties of the edible halophyte Carpobrotus edulis (L.) N.E.Br. towards neoformed food contaminants-related oxidative stress and genotoxicityeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleValorisation of halophyte plants present in Portuguese territory through the investigation of their protective effects against food toxicants - Study of bioactivities of plant-based products to attenuate the effects of food toxicants
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleExploring salt tolerant plants as sources of innovative food additives
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F135329%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBAA-AGR%2F1391%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.citation.startPage104447
oaire.citation.titleFood Bioscience
oaire.citation.volume61
oaire.fundingStreamPOR_NORTE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCustódio
person.givenNameLuísa
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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