Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/3992
Título: Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae
Autor: Guerreiro, P. M.
Fuentes, T.
Power, Deborah
Ingleton, P. M.
Flik, G.
Canario, Adelino V. M.
Palavras-chave: Hormone
N-terminal
Calcium regulation
Data: Set-2001
Editora: American Physiological Society
Citação: Guerreiro, P. M.; Fuentes, T.; Power, D. M.; Ingleton, P. M.; Flik, G.; Canario, A. V. M.Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 281, 3, R855-R860, 2001.
Resumo: The effects of an N-terminal peptide (amino acids 1-38) of Fugu parathyroid hormone-related protein (PTHrP 1-38) on calcium regulation of larval sea bream were investigated in seawater (36 per thousand) and after transfer to dilute seawater (12 per thousand). Exposure to PTHrP 1-38 evoked a 1.5-fold increase in calcium influx in both full-strength and dilute seawater. Calcium influx in dilute seawater-adapted larvae was roughly one-half that observed in full-strength seawater controls. PTHrP 1-38 also reduced drinking of fish in seawater but, at all concentrations tested, was without effect in dilute seawater. The amount of water imbibed was 55% lower in dilute seawater than in seawater. PTHrP 1-38 exposure affected the calcium influx route: the main contribution of calcium uptake shifted from intestinal absorption to extraintestinal uptake, probably by the induction of a dose-dependent increase in branchial (active) transport. Moreover, seawater-adapted fish exposed to 1 nM and 10 mM PTHrP 1-38 experienced a 2.5-fold reduction in overall calcium efflux. Overall, the calciotropic action of PTHrP 1-38 resulted in a dose-dependent increase in net calcium balance.
Descrição: Texto integral disponível através do editor
Peer review: yes
URI: http://hdl.handle.net/10400.1/3992
ISSN: 0363-6119
Versão do Editor: http://ajpregu.physiology.org/content/281/3/R855
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