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Browsing by Author "Afonso, Rita"

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  • Calcium/magnesium ratio in patients with diabetes and chronic kidney disease: a risk factor for cardiovascular disease
    Publication . Borges, Henrique; Afonso, Rita; Marques, Roberto Calças; Jerónimo, Teresa; Silva, Ana
    Chronic Kidney Disease (CKD) and Diabetes Mellitus (DM) are significant risk factors for Cardiovascular (CV) Disease. Patients with CKD and/or DM exhibit higher incidence and prevalence of CV events compared to the general population. Hypomagnesemia and elevated calcium-magnesium (Ca:Mg) ratios have been identified as independent risk factors for CV-related deaths. The aim of this study is to determine the relationship between Ca:Mg and the prognosis of CV disease in patients with CKD and DM.
    2023-06Conference object Open access Show more
  • Clinical characteristics and outcomes of PTLD after kidney transplant: a single center experience
    Publication . Afonso, Rita; Nicolau, Carla; Vieira, Miguel Bigotte; Caeiro, Fernando; Jorge, Cristina
    Post-Transplant Lymphoproliferative Disorder (PTLD) is a serious and potentially fatal complication of immunosuppression in kidney transplantation. Given the rarity of this entity, a high index of suspicion is necessary. We aimed to review the incidence, clinical presentation, histological subtypes, treatment, patient and graft survival of PTLD in kidney transplant patients in our unit.
    2024-05Conference object Open access Show more
  • Nephrotic syndrome in pregnant diabetic women: maternal and perinatal outcomes at a tertiary center
    Publication . Nogueira, Estela; Afonso, Rita; Godinho, Iolanda; Centeno, Mónica; Pinto, Luísa; Lopes, José António
    Management of pregnant women with diabetic kidney disease and nephrotic range proteinuria or nephrotic syndrome constitute a challenge to clinicians. Maternal and perinatal outcomes, especially in patients with chronic kidney disease, remain poor. The authors describe the multidisciplinary approach and the outcomes of diabetic pregnant patients with nephrotic range proteinuria.
    2023-06Conference object Open access Show more
  • The usefulness of calcium/magnesium ratio in the risk stratification of early onset of renal replacement therapy
    Publication . Afonso, Rita; Marques, Roberto; Borges, Henrique; Cabrita, Ana; Silva, Ana Paula
    A growing number of studies have reported a close relationship between high serum calcium (Ca)/low serum magnesium (Mg) and vascular calcification. Endothelial dysfunction and vascular inflammation seem plausible risk factors for the enhanced progression of kidney disease. The aim of this study was to evaluate the role of the Ca/Mg ratio as a predictor of the early onset of renal replacement therapy (RRT). Methods: This was a prospective study conducted in an outpatient low-clearance nephrology clinic, enrolling 693 patients with stages 4–5 of CKD. Patients were divided into two groups according to the start of renal replacement therapy (RRT). Results: The kidney’s survival at 120 months was 60% for a Ca–Mg ratio < 6 and 40% for a Ca–Mg ratio ≥ 6 (p = 0.000). Patients who started RRT had lower levels of Hb, Ca, Mg, albumin, and cholesterol and higher values of phosphorus, the Ca/Mg ratio, and PTH. High values of phosphorus and the Ca/Mg ratio and low levels of Mg and GFR were independent predictors of entry into RRT. A high Ca/Mg ratio, high phosphorus levels, and low levels of GFR were associated with a cumulative risk for initiation of RRT. Conclusions: In our population, the Ca/Mg ratio is an independent predictive factor for the initiation of a depurative technique.
    2022-10Journal article Open access Show more