Browsing by Author "Babych, Kateryna"
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- Deciphering the effects of metal-based drugs on cell signaling pathways in cancer cellsPublication . Babych, Kateryna; Marques, Vera Linda Ribeiro; León, Ignacio E.The term „cancer‟ encompasses a large group of diseases that are characterized by the development of abnormal cells, which divide, grow and spread without control in any part of the organism, spreading through blood or lymph vessels into surrounding tissues. Chemotherapy is a type of cancer treatment that uses drugs to kill cancer cells and is focused on stopping or slowing the growth of cancer cells, which divide abnormally and causes tumors. In most of the cases of chemotherapy prescription and selection of the specific drug, the more effective is a combination of two or more medications that, preferentially, should not interact with each other, either on their mechanism of action and/or their metabolism and elimination. Second and third generations of the existing drugs show increased bioactivity against cancer, but side effects are still a matter of concern. Recent studies show a significant interest in metal-based drugs, with some existing drugs being used already as antitumor agents, with proven effectiveness and fewer side effects, comparing to other drug treatments. Copper(II) as a metal and its complexes with various organic compounds have been reported to show cytotoxic activity at low concentrations. The aim of this work is to examine the effects of newly synthesized copper complexes in human cancer cell lines, both in terms of cytotoxicity and of mechanism of action. In this research work, two copper(II) based compounds were (copper(II)-tropolone and copper(II)-hinokitiol complexes), for their cytotoxic properties and tested in the human mammary breast cancer cell line MCF7 and MDA-MB-231 for their effect on viability, oxidative stress, apoptosis and interaction with DNA. Additionally, as a model for in vivo studies, the 3D model testing on cell viability was conducted and showed a positive result against MCF7 cell line survival. Together with that, the comparative analysis of complexes, its ligands and copper salt was performed. These compounds showed quite promising results in terms of their potential effect as antitumor drugs.