Percorrer por autor "Coelho, Ricardo"
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- zAvatar-test—a functional precision model to personalize ovarian cancer treatments: Results from a co-clinical studyPublication . Estrada, Marta F.; Amorim, Filipa; Silva, Filipa Ferreira da; Almeida, Cátia Rebelo de; Fontes, Márcia; Coelho, Ricardo; Ferreira, Sónia; Canas-Marques, Rita; Castillo-Martin, Mireia; Casanova, João; Batarda, Maria de Lurdes; Yaniz-Galende, Elisa; LeFormal, Audrey; Marreiros, Ana; Jacob, Francis; Heinzelmann-Schwarz, Viola; Leary, Alexandra; Nabais, Henrique; Fior, RitaIn ovarian cancer, 80% of patients relapse after first-line therapy. In recurrent cases, oncologists lack reliable tests to guide chemotherapy choices, creating an unmet clinical need. Here, we develop the ovarian cancer zebrafish Avatar-test, a functional in vivo model using patient tumor cells implanted in zebrafish embryos to predict treatment responses. We present the largest observational study (32 patients), where the zAvatar-test achieves 91% accuracy in predicting patient outcomes. Patients with a zAvatar-sensitive-test correlate with longer progression-free survival (17 vs. 6 months). Tumors in zAvatars are dynamic, with human-host cell interactions, and higher metastatic potential in poor-prognosis cases. Finally, as a proof of concept, we demonstrate that venetoclax has the potential to sensitize multidrug-resistant tumors. Altogether, this clinical study demonstrates that the zAvatar-test may help clinicians personalize treatments for ovarian cancer patients. We are now conducting a multicentric randomized clinical trial to evaluate the zAvatar-test as a companion tool in clinical oncology.