Browsing by Author "Grougnet, Raphael"
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- Chemical composition, antibacterial screening and cytotoxic activity of Chiliadenus antiatlanticus (Asteraceae) essential oilPublication . El Yaagoubi, Mohamed; Ortiz, Sergio; Mechqoq, Hicham; Cavaleiro, Carlos; Lecso-Bornet, Marylin; Rodrigues, Maria Joao; Custódio, Luísa; El Mousadik, Abdelhamid; Grougnet, Raphael; El Aouad, Noureddine; Msanda, Fouad; Kritsanida, MarinaThe chemical composition and in vitro antibacterial and cytotoxic activities of the essential oil (EO) of Chiliadenus antiatlanticus (Emb. & Maire) Gomiz, an asteraceous species endemic to the southwest of Morocco, were investigated. The EO yield was 1.07 +/- 0.28 %, twenty-seven metabolites were identified representing more than 96.4 % of the total composition. Camphor (35.7 %) and derivatives, borneol (4.9 %) and camphene (4.2 %) together with intermedeol (19.9 %), alpha-pinene (15.5 %) and (E)-pinocarveol (4.1 %) were the major constituents. An antibacterial activity was noticed against 24 strains (all Gram-positive) out of 71 at MICs values=100 mu g/mL. The EO also showed significant toxicity towards liver HepG2 (55.8 % of cell viability) and melanoma B16 4A5 (41.6 % of cell viability) tumor cell lines at 100 mu g/mL.