Percorrer por autor "Oliveira, Marta Margarida de Figueiredo"
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- Unlocking the potential of extremophile plants from maritime environments as sources of innovative products for use in veterinary sciencesPublication . Oliveira, Marta Margarida de Figueiredo; Custódio, Luísa; Hoste, Hervé; Barreira, LuísaMediterranean salt-tolerant plants, adapted to challenging conditions, are underlooked as sustainable anthelmintic solutions for ruminants, offering potential for livestock management, particularly in areas where saline or degraded soils restrict traditional agricultural productivity. With this in mind, the main goal of this dissertation is to valorize Mediterranean salt-tolerant plant species for the management of gastrointestinal nematode (GIN) infections in ruminants, either as nutraceutical plants or phytotherapeutic options. Target species were Pistacia lentiscus L., Helichrysum italicum subsp. picardii (Boiss. & Reut.) Franco, Inula crithmoides L., Calystegia soldanela (L.) R.Br., Cladium mariscus (L.) Pohl, Medicago marina L., Plantago coronopus L., Limoniastrum monopetalum L. Boiss, and Crucianella marítima L.. Chemical analyses disclose that these species are rich in minerals and phenolics, valued for their antioxidant properties, making them promising for nutraceutical and phytotherapeutic applications. Exploring seasonal variations allowed the selection of samples with the highest phenolic content and antioxidant properties, ensuring prioritization in the phytotherapeutic pipeline. In vitro anthelmintic assays revealed that 80% acetone extracts of P. lentiscus, H. italicum picardii, C. mariscus, and L. monopetalum were highly effective against egg hatching and larval exsheathment of the clinically relevant gastrointestinal nematodes Haemonchus contortus and Trichostrongylus colubriformis. After, a PVPP-HPLC-ESI MSn approach identified potential bioactive metabolites contributing to the activity of each species. For C. mariscus, seasonal variations allied to organ occurrence, and despite anthelmintic effects were observed year-round, inflorescences exhibited the strongest activity against egg hatching. In vivo trials showed that a single oral dose of C. mariscus and L. monopetalum extracts in GIN-infected lambs had no significant effect on parasitological status but led to slight improvements in hematological parameters. In the end, this dissertation provided new insights into the biochemical potential of salt-tolerant species targeting GIN infections in ruminants, highlighting their applications in this scope and opening novel avenues for innovative anthelmintic solutions in ruminant production.