Browsing by Author "Rodrigues, Carolina"
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- Influencing factors of the innovation power in the adoption of sustainability strategiesPublication . Barbieri da Rosa, Luciana Aparecida; Gomes, Clandia Maffini; Campos, Waleska; Rodrigues, Carolina; Godoy, Tais Pentiado; Kneipp, Jordana MarquesThe study aimed to analyze which are the best corporate environmental strategies to foster the innovation power of companies in the mining sector. The methodology used was the quantitative approach through multiple linear regression analysis were used to analyze the power of innovation and to see how the interrelationship between pressures and incentives can influence companies in the implementation of the sustainability strategy which resulted in five different models. The results show that different environmental strategies foster, in different ways, the power of innovation of companies in the analyzed mineral sector. Therefore, it became evident that cost reduction and adaptation to a strong regulatory environment are strategies capable of promoting external guidance and the transparency of innovation processes. Second, the search for reducing environmental impacts and adapting to a strong regulatory environment are strategies that strengthen knowledge of the business environment. In addition, the results show that leadership in products and processes can be optimized through strategies to reduce costs and environmental impacts. Finally, Autonomy and market leadership in relation to innovative initiatives can be achieved via cost reduction, incorporation of social and environmental guidelines, and adaptation to a strong regulatory environment. Thus, this study contributes to the theory and practice of innovation as it reveals to be the best corporate strategy capable of fostering the innovation power of companies in the mineral sector.
- A randomized controlled trial assessing the release of circulating tumor and mesenchymal cells in no-touch radical nephrectomyPublication . Leitão, Tito Palmela; Corredeira, Patrícia; Rodrigues, Carolina; Piairo, Paulina; Miranda, Miguel; Martins Cavaco, Ana Cláudia; Kucharczak, Sandra; Antunes, Marília; Peixoto, Sara; Reis, José Palma dos; Lopes, Tomé; Diéguez, Lorena; Costa, LuísAbstract: Background: Circulating tumor cells (CTCs) may be the missing renal cell carcinoma (RCC) biomarker. No-touch (NT) resection has shown benefit in several tumors. Methods: A randomized controlled trial comparing CTC and circulating mesenchymal cell (CMC) release in no-touch (NT) vs. conventional (C) laparoscopic RN. Blood samples were collected at operation room arrival (S0), specimen extraction (S1), postoperative D1, and D30. CTCs were isolated and analyzed using RUBYchip™. Results: Thirty-four patients were included. No significant differences were found between groups in CTC and CMC counts, count variations between time points, complications, and survival. The total circulating cell detection rates in the NT, C, and overall RCC groups were 58.3%, 80.0%, and 70.4% at S0; 41.6%, 86.7%, and 66.7% at S1; 50.0%, 64.3%, and 60.0% at D1; and 54.5%, 42.9%, and 44.0% at D30, respectively. A progressive decrease in CMCs was observed in the C group after surgery, especially at D1 (4.78 to 1.64 CMCs/7.5 mL blood, p = 0.035). Healthy controls had no circulating cells; however, high CMC counts were found in chronic inflammation controls and oncocytoma patients, with no significant difference from RCC patients (p = 0.460). Conclusions: NT RN did not reduce circulating cell release nor improve survival compared to C RN.