Percorrer por autor "Saadellaoui, Wissal"
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- Mediterranean asteraceae as natural sources of antioxidants and enzyme inhibitors: a case study on urospermum dalechampii and andryala integrifolia from TunisiaPublication . Hammami, Nourhen; Rodrigues, Maria João; Fernandes, Eliana; Stegemann, Thomas; Saadellaoui, Wissal; Hannachi, HédiaThis study investigated the phenolic composition, antioxidant capacity, and key enzyme-inhibitory activities of hydroethanolic leaf extracts from two Mediterranean Asteraceae, Urospermum dalechampii and Andryala integrifolia, from Tunisia. U. dalechampii exhibited higher total phenolic content (62.84 mg GAE/g crude extract), whereas A. integrifolia showed higher flavonoids (34.55 mg QE/g crude extract). The UHPLC-DAD-MS analysis revealed caffeoylquinic acid isomers, flavonols (quercetin and kaempferol types), and flavones (luteolin derivatives) in both species, while cynarine was detected in U. dalechampii. Some compounds were specific, such as caftaric acid, which was detected only in U. dalechampii leaf extract. Both species exhibited notable antioxidant capacities, with U. dalechampii showing stronger radical-scavenging activity (DPPH: EC50 = 0.95 mg/mL; ABTS: EC50 = 0.72 mg/mL), whereas A. integrifolia displayed higher reducing power (FRAP: EC50 = 5.40 mg/mL) and copper-chelating activity (EC50 = 1.72 mg/mL). A. integrifolia showed marked inhibition of tyrosinase (IC50 = 0.54 mg/mL), α-glucosidase (IC50 = 1.9 mg/mL), and lipase (IC50 = 9.7 mg/mL). Both leaf extracts from studied species inhibited AChE, while only A. integrifolia inhibited BChE (IC50 = 8.63 mg/mL). No cytotoxicity was detected at 100 μg/mL in human hepatocarcinoma (HepG2), neuroblastoma (SH-SY5Y), embryonic kidney (HEK-293), and murine melanoma (B16) cells. These results highlight these two plants as a promising source of multifunctional bioactive compounds and demonstrate that unexploited wild plants could offer new prospects for pharmaceutical and nutraceutical applications.
- Nutritional composition of the unexplored mediterranean plant urospermum dalechampii (L.) Scop. ex F.W.Schmidt from TunisiaPublication . Hammami, Nourhen; Rodrigues, Maria João; M’rabet, Yassine; Saadellaoui, Wissal; Hosni, Karim; Stambouli-Essassi, Sondes; Hannachi, HédiaUrospermum dalechampii (L.), commonly known as Mediterranean daisy, is an unexplored herbaceous species from the Asteraceae family. This study aims to compare the proximate composition, mineral content and fatty acid profile of its aerial parts and roots. Carbohydrates (46.60–78.00 %), proteins (5.40–13.50 %) and crude fiber (10.40–24.60 %) were the major components in both parts. Ash content were significantly (p < 0.05) higher in aerial parts (13.80 %) and was predominantly composed of potassium, calcium and sodium as macroelements, while iron, zinc and copper were the major trace elements. The oil contents were low in the both studied parts (1.00–1.50 %) and were mostly composed of unsaturated fatty acids (oleic > linolenic > linoleic in the aerial parts versus oleic > linoleic > linolenic in roots) with high nutritional quality having high UFA/SFA, ω-3/ω-6 ratios, low AI, TI and h/H indexes. These results revealed that Urospermum dalechampii could serves as a source of essential minerals, fatty acids, fiber, protein, carbohydrates reflecting its potential applications in food/feed and pharmaceutical fields.