Browsing by Author "Teixeira, Diogo Tiago Portela"
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- Insights into the role of G3BP1 on Polyglutamine diseasesPublication . Teixeira, Diogo Tiago Portela; Nóbrega, Clévio; Matos, CarlosSpinocerebellar Ataxia type 3, also known as Machado-Joseph disease (SCA3/MJD) and Spinocerebellar Ataxia type 2 (SCA2), are the most and second most common forms of ataxia worldwide, respectively. They are polyglutamine diseases, which gene products codify a mutant protein with an abnormal CAG trinucleotide expansion. This will provoke the formation of toxic insoluble aggregates in the affected neurons. In a disease context stressful situation cells are prone to form stress granules (SGs) that are responsible for accumulate stalled untranslated mRNAs, proteins and several other macromolecules.(...)