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Browsing by Author "Trombini, Chiara"

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  • Biomarkers in nereis diversicolor (Polychaeta: Nereididae) as management tools for environmental assessment on the southwest Iberian coast
    Publication . Gomes, Tânia; Gonzalez-Rey, Maria; Rodriguez-Romero, Araceli; Trombini, Chiara; Riba, Immaculada; Blasco, Julian; Bebianno, Maria João
    The environmental quality of the southwest Iberian coast was assessed in different areas (Ria Formosa Lagoon, Guadiana Estuary and Cadiz Bay) focusing on metal contamination (Cd, Cu, Ni, Pb and Zn) in Nereis diversicolor whole tissues. In addition, associated toxicological effects were assessed using a multibiomarker approach combining several conventional biomarkers. The set of biomarkers selected included antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase), metallothionein and lipid peroxidation. N. diversicolor from the Ria Formosa Lagoon, Guadiana River and Cadiz Bay responded differently to metal contamination with different biomarker responses showing a clear site trend, suggesting different sources and/or magnitudes of contamination. Cadmium was a source of oxidative stress in polychaetes, mainly in Cadiz Bay, with a significant influence on antioxidant enzymes and enhancement of lipid peroxidation. The highest MT concentrations were in the Ria Formosa Lagoon and in the Guadiana River, where there was a direct relationship with high nickel concentrations. Biomarker responses of N. diversicolor are useful tools for environmental quality assessment on the southwest Iberian coast, and more specific metal biomarkers should be included in future assessments.
    2013-01Journal article Open access Show more
  • Toxic effects of cisplatin cytostatic drug in mussel Mytilus galloprovincialis
    Publication . Trombini, Chiara; da Fonseca, Taina Garcia; Morais, Matilde; Rocha, Thiago Lopes; Blasco, Julian; Bebianno, Maria João
    Antineoplastic drugs used in chemotherapy were detected in aquatic environment: despite the very low concentrations (ng L-1 to ug L-1), due to their potent mechanism of action they could have adverse effects on non-target aquatic organisms particularly under chronic exposure. Cisplatin (CDDP) is one of the most effective anticancer drug currently in use but information on its ecotoxicological effects is very limited. In this study, Mytilus galloprovincialis was used to investigate the toxic effects related to CDDP exposure. Mussels were exposed to cisplatin (100 ng L-1) for 14 days: antioxidant (superoxide dismutase, catalase, total and selebium-dependent glutathione peroxidase) and phase II (glutathione-S-transferase) enzymes activities, oxidative damage (lipid peroxidation), genotoxicity (DNA damage) and neurotoxicity (acetylcholinesterase) was evaluated. Results indicate that CDDP at tested concentration induce changes in the antioxidant capacity, oxidative stress in target organs (digestive gland and gills) as well as DNA damage in mussel hemocytes and neurotoxicity representing a risk for non-target organisms. (C) 2016 Elsevier Ltd. All rights reserved.
    2016-08Journal article Restricted access Show more