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- Analysis of behaviours and attitudes of antibiotics use in Algarve's populationPublication . F. Marques, C.; Amado, A.; Ramalhinho, I. R.Background and objective: In the past years, the antimicrobial resistance has been increasing, partly due to its misuse, and this has been considered as a threat for the public health by WHO. The aim of this study was to evaluate behaviours and attitudes of antibiotics use among adults in the south region of Portugal, Algarve, particularly self-medication and knowledge about these drugs.
- Synthesis and anti-cancer activity of chiral tetrahydropyrazolo[1,5-a] pyridine-fused steroidsPublication . Lopes, Susana M. M.; Sousa, Emanuel P.; Barreira, Luísa; F. Marques, C.; Rodrigues, Maria João; Pinho e Melo, Teresa M. V. D.Regio-and stereoselective synthesis of novel chiral 4,5,6,7-tetrahydropyrazolo [1,5-a]pyridine fused steroids via [8 pi + 2 pi] cycloaddition of diazafulvenium methides with steroidal scaffolds is reported. The biological evaluation of the new family of hexacyclic steroids as anti-cancer agents was also carried out. Hexacyclic steroids bearing a benzyl group at C-22, derived from 16-dehydropregnenolone and 16-dehydroprogesterone, show considerable cytotoxicity against EL4 (murine T-lymphoma) in contrast with the corresponding C-22-unsubstituted derivatives showing low cytotoxicity. Thus, results indicate that the presence of the benzyl group is important to ensure cytotoxicity.