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- Sulphated locust bean gum-coated lipid nanocapsules as potential lung delivery carriersPublication . Pontes, Jorge Filipe; Braz, L.; Guerreiro, Filipa; Rosa Da Costa, Ana; Almouazen, Eyad; Lollo, Giovanna; Grenha, AnaDrugs pertaining to Biopharmaceutics Classification System (BCS) classes II and IV have limitations in their delivery, including in the lung. Therefore, drug delivery carriers have been proposed to improve the therapeutic effectiveness of such drugs. This work proposes lipid nanocapsules (LNC) as a potential platform for lung drug delivery. Locust bean gum (LBG), which is a galactomannan, was used as polymeric shell, protecting the oily core of the nanocapsules and providing their surface with hydrophilic character. Due to the neutral character of LBG, in order to enable nanocapsule formation, a sulphate derivative (LBGS) was prepared, which was confirmed by Fourier-transformed infrared (FTIR) spectroscopy. The electrostatic interaction between the negatively charged sulphate groups of LBGS and the positively charged groups of the used cationic lipid (1,2-dioleoyloxy-3- trimethylammoniumpropanchloride, DOTAP), allowed the formation of monodisperse nanocapsules, with sizes around 200 nm and strongly negative zeta potentials, between -70 and -85 mV. Envisaging potential lung drug delivery, the LBGS-coated LNC were co-formulated with mannitol using spray-drying, producing microencapsulated nanocapsules. Feret’s diameter was determined to be 2.6 ± 1.8 µm and 3.1 ± 1.9 µm for Man (control) and Man/LNC microparticles, respectively. Further studies are underway in order to optimise both the nanoplatform and the dry powder formulation.
- Statement of Peer ReviewPublication . De Sousa-Coelho, Ana Luísa; Teotónio Fernandes, Mónica Alexandra; Estêvão, Maria Dulce da Mota Antunes de Oliveira ; Neto Espírito-Santo, Margarida de Fátima; Braz, Luis; Nascimento, TâniaIn submitting conference proceedings to Proceedings, the volume editors of the proceedings certify to the publisher that all papers published in this volume have been subjected to peer review administered by the volume editors. The reviews were conducted by expert referees, and to the professional and scientific standards expected of a proceedings journal.
- Preface: VII Poster Sunset Session—ESSUAlg 2024Publication . De Sousa-Coelho, Ana Luísa; Teotónio Fernandes, Mónica Alexandra; Estêvão, Maria Dulce da Mota Antunes de Oliveira ; Braz, Luis; Nascimento, TâniaThe event “Poster Sunset Session” began in 2017 at the School of Health of the University of Algarve (ESSUAlg), bringing the premise that scientific knowledge depends on research and critical analysis and that the exchange of ideas and information is an essential part of the continuous development process. This event was conceptualized and prepared by professors of the Pharmacy Department at ESSUAlg. The idea of “sunset” was based on the beautiful view over Ria Formosa (Faro, Portugal) that the previous building of ESSUAlg offered at dusk.