INVESTIGATION OF STRUCTURAL EFFECTS ON THE REACTIVITY OF HETEROCYCLIC BIOACTIVE COMPOUNDS

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Synthesis and structure of novel benzisothiazole-tetrazolyl derivatives for potential application as nitrogen ligands

Publication . Frija, L.; Fausto, R.; Loureiro, Rui M. S.; Cristiano, Maria Lurdes Santos

The synthesis and characterization of novel benzisothiazole-tetrazolyl derivatives differing on the spacer-group used for the linkage of two heterocycles are described. The application of these compounds as nitrogen ligands for coordination with transition metals was also explored, leading to the preparation of 3-[1-(2-1H-tetrazol-5-yl)ethoxy]-1,2-benzisothiazole 1,1-dioxide-Mn(II) and N-(1,1-dioxo-1,2-benzisothiazol-3-yl)-amine-1H-tetrazole-Mn(II) complexes.

2009Journal article

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