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Western outcomes of circumferential endoscopic submucosal dissection for early esophageal squamous cell carcinoma

dc.contributor.authorde Santiago, Enrique Rodríguez
dc.contributor.authorvan Tilburg, Laurelle
dc.contributor.authorDeprez, Pierre H.
dc.contributor.authorPioche, Mathieu
dc.contributor.authorPouw, Roos E.
dc.contributor.authorBourke, Michael J.
dc.contributor.authorSeewald, Stefan
dc.contributor.authorWeusten, Bas L.A.M.
dc.contributor.authorJacques, Jeremie
dc.contributor.authorLeblanc, Sara
dc.contributor.authorBarreiro, Pedro
dc.contributor.authorLemmers, Arnaud
dc.contributor.authorParra-Blanco, Adolfo
dc.contributor.authorMagalhães, Ricardo Küttner
dc.contributor.authorLibânio, Diogo
dc.contributor.authorMessmann, Helmut
dc.contributor.authorAlbéniz, Eduardo
dc.contributor.authorKaminski, Michal F.
dc.contributor.authorMohammed, Noor
dc.contributor.authorRamos-Zabala, Felipe
dc.contributor.authorHerreros-de-Tejada, Alberto
dc.contributor.authorKoecklin, Hugo Huchima
dc.contributor.authorWallenhorst, Timothée
dc.contributor.authorAntunes, João Santos
dc.contributor.authorNeves, João A. Cunha
dc.contributor.authorKoch, Arjun D.
dc.contributor.authorAyari, Myriam
dc.contributor.authorDuran, Rodrigo Garces
dc.contributor.authorPonchon, Thierry
dc.contributor.authorRivory, Jérôme
dc.contributor.authorBergman, Jacques J.G.H.M.
dc.contributor.authorVerheij, Eva P.D.
dc.contributor.authorGupta, Sunil
dc.contributor.authorGroth, Stefan
dc.contributor.authorLepilliez, Vincent
dc.contributor.authorFranco, Ana Rita
dc.contributor.authorBelkhir, Sanaa
dc.contributor.authorWhite, Jonathan
dc.contributor.authorEbigbo, Alanna
dc.contributor.authorProbst, Andreas
dc.contributor.authorLegros, Romain
dc.contributor.authorPilonis, Nastazja Dagny
dc.contributor.authorde Frutos, Diego
dc.contributor.authorMuñoz González, Raquel
dc.contributor.authorRibeiro, Mário Dinis
dc.date.accessioned2024-12-17T13:11:02Z
dc.date.available2024-12-17T13:11:02Z
dc.date.issued2024-04
dc.description.abstractBackground and Aims: Circumferential endoscopic submucosal dissection (cESD) in the esophagus has been reported to be feasible in small Eastern case series. We assessed the outcomes of cESD in the treatment of early esophageal squamous cell carcinoma (ESCC) in Western countries. Methods: We conducted an international study at 25 referral centers in Europe and Australia using prospective databases. We included all patients with ESCC treated with cESD before November 2022. Our main outcomes were curative resection according to European guidelines and adverse events. Results: A total of 171 cESDs were performed on 165 patients. En bloc and R0 resections rates were 98.2% (95% confidence interval [CI], 95.0-99.4) and 69.6% (95% CI, 62.3-76.0), respectively. Curative resection was achieved in 49.1% (95% CI, 41.7-56.6) of the lesions. The most common reason for noncurative resection was deep submucosal invasion (21.6%). The risk of stricture requiring 6 or more dilations or additional techniques (incisional therapy/stent) was high (71%), despite the use of prophylactic measures in 93% of the procedures. The rates of intraprocedural perforation, delayed bleeding, and adverse cardiorespiratory events were 4.1%, 0.6%, and 4.7%, respectively. Two patients died (1.2%) of a cESD-related adverse event. Overall and disease-free survival rates at 2 years were 91% and 79%. Conclusions: In Western referral centers, cESD for ESCC is curative in approximately half of the lesions. It can be considered a feasible treatment in selected patients. Our results suggest the need to improve patient selection and to develop more effective therapies to prevent esophageal strictures.eng
dc.identifier.doi10.1016/j.gie.2023.10.042
dc.identifier.issn0016-5107
dc.identifier.urihttp://hdl.handle.net/10400.1/26501
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.hasversionhttps://www.giejournal.org/article/S0016-5107(23)02997-8/fulltext
dc.relation.ispartofGastrointestinal Endoscopy
dc.rights.uriN/A
dc.titleWestern outcomes of circumferential endoscopic submucosal dissection for early esophageal squamous cell carcinomaeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage524.e6
oaire.citation.issue4
oaire.citation.startPage511
oaire.citation.titleGastrointestinal Endoscopy
oaire.citation.volume99
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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