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P-selectin glycoprotein ligand 1 promotes T cell lymphoma development and dissemination

2021-08Journal article Open access
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dc.contributor.authorPereira, João L.
dc.contributor.authorCavaco, Patrícia
dc.contributor.authorda Silva, Ricardo C.
dc.contributor.authorPacheco-Leyva, Ivette
dc.contributor.authorMereiter, Stefan
dc.contributor.authorPinto, Ricardo
dc.contributor.authorReis, Celso A.
dc.contributor.authorRodrigues Dos Santos, Nuno
dc.date.accessioned2021-09-14T15:44:50Z
dc.date.available2021-09-14T15:44:50Z
dc.date.issued2021-08
dc.description.abstractP-selectin glycoprotein ligand-1 (PSGL-1) is a membrane-bound glycoprotein expressed in lymphoid and myeloid cells. It is a ligand of P-, E- and L-selectin and is involved in T cell trafficking and homing to lymphoid tissues, among other functions. PSGL-1 expression has been implicated in different lymphoid malignancies, so here we aimed to evaluate the involvement of PSGL-1 in T cell lymphomagenesis and dissemination. PSGL-1 was highly expressed at the surface of human and mouse T cell leukemia and lymphoma cell lines. To assess its impact on T cell malignancies, we stably expressed human PSGL-1 (hPSGL-1) in a mouse thymic lymphoma cell line, which expresses low levels of endogenous PSGL-1 at the cell surface. hPSGL-1-expressing lymphoma cells developed subcutaneous tumors in athymic nude mice recipients faster than control empty vector or parental cells. Moreover, the kidneys, lungs and liver of tumor-bearing mice were infiltrated by hPSGL-1-expressing malignant T cells. To evaluate the role of PSGL-1 in lymphoma cell dissemination, we injected intravenously control and hPSGL 1-expressing lymphoma cells in athymic mice. Strikingly, PSGL-1 expression facilitated disease infiltration of the kidneys, as determined by histological analysis and anti-CD3 immunohistochemistry. Together, these results indicate that PSGL-1 expression promotes T cell lymphoma development and dissemination to different organs.pt_PT
dc.description.sponsorshipNORTE-01-0145-FEDER-000029; POCI-01-0145-FEDER-007274
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.tranon.2021.101125pt_PT
dc.identifier.issn1936-5233
dc.identifier.urihttp://hdl.handle.net/10400.1/17108
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCentre for Biomedical Research
dc.relationPSGL-1 inactivation: A two-prong strategy to target lymphoma
dc.relationThymic microenvironmental factors fostering T-cell malignant transformation
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectP-selectin glycoprotein ligand 1pt_PT
dc.subjectLymphomapt_PT
dc.subjectT cellpt_PT
dc.subjectTumorigenesispt_PT
dc.subjectDisseminationpt_PT
dc.titleP-selectin glycoprotein ligand 1 promotes T cell lymphoma development and disseminationpt_PT
dc.title.alternativeLigante de glicoproteína p-selectin 1 promove desenvolvimento e disseminação de linfoma de células Tpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Biomedical Research
oaire.awardTitlePSGL-1 inactivation: A two-prong strategy to target lymphoma
oaire.awardTitleThymic microenvironmental factors fostering T-cell malignant transformation
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/75445/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Projectos de I&D em todos os Domínios Científicos - 2008/PTDC%2FSAU-OBD%2F103336%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017/PTDC%2FMED-ONC%2F32592%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F147979%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00056%2F2012%2FCP0164%2FCT0002/PT
oaire.citation.issue8pt_PT
oaire.citation.startPage101125pt_PT
oaire.citation.titleTranslational Oncologypt_PT
oaire.citation.volume14pt_PT
oaire.fundingStreamPOR_NORTE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso para Projectos de I&D em todos os Domínios Científicos - 2008
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamInvestigador FCT
person.familyNameRodrigues dos Santos
person.givenNameNuno
person.identifier.orcid0000-0001-7347-2592
person.identifier.scopus-author-id7006810054
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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