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The diverse roles of T cell subsets in asthma

2021-09Journal article Open access
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dc.contributor.authorRegateiro, F.S.
dc.contributor.authorBotelho Alves, P.
dc.contributor.authorMoura, A.L.
dc.contributor.authorAzevedo, J.P.
dc.contributor.authorRegateiro, Frederico S.
dc.date.accessioned2021-09-28T12:41:57Z
dc.date.available2021-09-28T12:41:57Z
dc.date.issued2021-09
dc.description.abstractAsthma is a heterogeneous disease. Several distinct clinical phenotypes have been described and it is now debated whether asthma is a “single disease” or, instead, a group of inflammatory lung diseases with similar manifestations but diverse pathophysiology. More recently, these underlying inflammation mechanisms have been used to classify asthma into “endotypes” (1). Although several markers have been proposed to distinguish specific asthma endotypes (e.g., IgE sensitization in allergic asthma, peripheral eosinophil counts in eosinophilic asthma, periostin in Th2-high asthma, etc.), the most consensual distinction is based on the CD4+ T-helper (Th) cytokine profiles involved (i.e., Th2-high vs Th2-low), therefore illustrating the central role of these cells in asthma. T cells are central coordinators of the immune response. T-cell receptor (TCR) recognition is crucial for the initiation and specificity of the adaptive immune response, while T cell dervied cytokines tailor the type of immune response. Asthma is an inflammatory lung disease and T cells have been shown to play a central role in the pathophysiology of the disease. A good understanding of T cells in asthma is also important for therapeutic reasons, in particular for the choice of biological treatments in severe asthma. T cells are generally divided into two major types: CD4+ T cells and CD8+ T cells. CD4+ T cell are activated by antigen presented by major histocompatibility complex (MHC) class II on the surface of professional antigen-presenting cells (APC), whereas CD8+T cells recognize antigens presented by MHC class I on the surface of all nucleated cells. As discussed below, each of these types can be subdivided into several functionally distinct subtypes. Classically, asthma has been considered a Th2-mediated inflam matory disease. However, more recent studies have identified contributing roles for other types of T cells in the pathophysiology and the heterogeneity of the disease. In this chapter, we review how the different types and subtypes of T cells are involved in asthma and its phenotypes/endotypes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.23822/EurAnnACI.1764-1489.177pt_PT
dc.identifier.issn1764-1489
dc.identifier.urihttp://hdl.handle.net/10400.1/17166
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEDRA SPApt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAsthmapt_PT
dc.subjectT cellspt_PT
dc.subjectRegulatory T cellspt_PT
dc.subjectAsthma endotypespt_PT
dc.subjectAsthma biomarkerspt_PT
dc.titleThe diverse roles of T cell subsets in asthmapt_PT
dc.title.alternativeOs diversos papéis dos subconjuntos de células T na asmapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue05pt_PT
oaire.citation.startPage201pt_PT
oaire.citation.titleEuropean Annals of Allergy and Clinical Immunologypt_PT
oaire.citation.volume53pt_PT
person.familyNameRegateiro
person.givenNameFrederico
person.identifier.ciencia-id1111-B78A-6EC2
person.identifier.orcid0000-0002-6332-3056
person.identifier.ridF-3914-2011
person.identifier.scopus-author-id8859661600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione68bb116-da90-47f8-bbf6-08a097ff8aca
relation.isAuthorOfPublication.latestForDiscoverye68bb116-da90-47f8-bbf6-08a097ff8aca

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