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Annexin A2: The Importance of Being Redox Sensitive

2013-02Journal article Open access
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dc.contributor.authorMadureira, Patricia
dc.contributor.authorWaisman, David M.
dc.date.accessioned2018-12-07T14:52:58Z
dc.date.available2018-12-07T14:52:58Z
dc.date.issued2013-02
dc.description.abstractHydrogen peroxide (H2O2) is an important second messenger in cellular signal transduction. H2O2-dependent signalling regulates many cellular processes, such as proliferation, differentiation, migration and apoptosis. Nevertheless, H2O2 is an oxidant and a major contributor to DNA damage, protein oxidation and lipid peroxidation, which can ultimately result in cell death and/or tumourigenesis. For this reason, cells have developed complex antioxidant systems to scavenge ROS. Recently, our laboratory identified the protein, annexin A2, as a novel cellular redox regulatory protein. Annexin A2 possesses a reactive cysteine residue (Cys-8) that is readily oxidized by H2O2 and subsequently reduced by the thioredoxin system, thereby enabling annexin A2 to participate in multiple redox cycles. Thus, a single molecule of annexin A2 can inactivate several molecules of H2O2. In this report, we will review the studies detailing the reactivity of annexin A2 thiols and the importance of these reactive cysteine(s) in regulating annexin A2 structure and function. We will also focus on the recent reports that establish novel functions for annexin A2, namely as a protein reductase and as a cellular redox regulatory protein. We will further discuss the importance of annexin A2 redox regulatory function in disease, with a particular focus on tumour progression.
dc.description.sponsorshipEuropean Union Seventh Framework Programme (FP7) [PCOFUND-GA-2009-246542]; Foundation for Science and Technology of Portugal; Natural Sciences and Engineering Research Council of Canada (NSERC)
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3390/ijms14023568
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.1/11286
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationWORK PLAN FOR RESEARCH FELLOWSHIP PCOFUND-GA-2009-246542
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNecrosis-factor-Alpha
dc.subjectTissue-plasminogen-activator
dc.subjectColony-stimulating factor
dc.subjectCellular-binding sites
dc.subjectNadph Oxidase
dc.subjectHydrogen-Peroxide
dc.subjectIi Tetramer
dc.subjectOxidative stress
dc.subjectTyrosine Kinase
dc.subjectDna-Damage
dc.titleAnnexin A2: The Importance of Being Redox Sensitive
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleWORK PLAN FOR RESEARCH FELLOWSHIP PCOFUND-GA-2009-246542
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBI%2F52182%2F2013/PT
oaire.citation.endPage3594
oaire.citation.issue2
oaire.citation.startPage3568
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.citation.volume14
person.familyNameMadureira
person.givenNamePatricia
person.identifier.ciencia-id6612-9A86-6929
person.identifier.orcid0000-0002-4856-3908
person.identifier.scopus-author-id10340140500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationa40de6a3-d52d-45dd-8620-cb94a22ebc8f
relation.isAuthorOfPublication.latestForDiscoverya40de6a3-d52d-45dd-8620-cb94a22ebc8f
relation.isProjectOfPublication976621e4-7a18-46a8-af37-c0a4e4b78ca3
relation.isProjectOfPublication.latestForDiscovery976621e4-7a18-46a8-af37-c0a4e4b78ca3

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