Repository logo
 
Publication

Clinical outcomes of percutaneous coronary intervention in chronic total occlusion in patients with type 2 diabetes mellitus

2024-04Journal article Open access
Simple item page
dc.contributor.authorCosta, Hugo
dc.contributor.authorEspírito-Santo, Miguel
dc.contributor.authorBispo, João
dc.contributor.authorGuedes, João
dc.contributor.authorMimoso, Jorge
dc.contributor.authorPalmeiro, Hugo
dc.contributor.authorGonçalves, Rui Baptista
dc.contributor.authorVinhas, Hugo
dc.date.accessioned2024-11-22T13:58:49Z
dc.date.available2024-11-22T13:58:49Z
dc.date.issued2024-04
dc.description.abstractIntroduction and Objectives: Coronary chronic total occlusions (CTOs) are relatively common findings in patients with type 2 diabetes mellitus (T2DM). However, the indication for percutaneous coronary intervention (PCI) and its clinical benefit in these patients remain controversial. Methods: A single-center retrospective cohort study with prospectively collected outcomes was carried out with CTO patients undergoing PCI in 2019 and 2020. Patients were divided into two groups according to previous T2DM diagnosis (T2DM and non-T2DM). The primary outcome was recurrence of angina and/or heart failure symptoms and secondary outcomes were myocardial infarction and all -cause mortality. Results: A total of 177 patients (82.5% male) were included in the analysis, with a mean age of 65 +/- 11 years. The primary outcome (total symptom recurrence) occurred in 16.6% of the sample, with no difference between groups (non-T2DM 13.6% vs. T2DM 21.2%, p=0.194) in a two-year follow-up. Angina recurrence was significantly more frequent in T2DM patients (15.2%, p=0.043). The presence of T2DM was not an independent predictor of symptom recurrence (p=0.429, HR 1.37, 95% CI 0.62 - 2.98). Myocardial infarction and all -cause mortality were also not different between groups (T2DM 1.5%, p=0.786 and 4.5%, p=0.352, respectively, on survival analysis). Independent predictors of all -cause mortality were left ventricular function and creatine clearance (p=0.039, HR 0.92, 95% CI 0.85 - 0.99 and p=0.013, HR 0.96, 95% CI 0.93 - 0.99, respectively). Conclusions: T2DM did not influence outcomes in CTO patients undergoing PCI, and its presence should not be a limiting factor in deciding on CTO revascularization.eng
dc.identifier.doi10.1016/j.repc.2023.07.009
dc.identifier.issn0870-2551
dc.identifier.urihttp://hdl.handle.net/10400.1/26326
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0870255123004997?via%3Dihub
dc.relation.ispartofRevista Portuguesa de Cardiologia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectChronic total occlusions
dc.subjectClinical outcomes
dc.subjectType 2 diabetes
dc.subjectSymptom recurrence
dc.titleClinical outcomes of percutaneous coronary intervention in chronic total occlusion in patients with type 2 diabetes mellituseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage174
oaire.citation.issue4
oaire.citation.startPage167
oaire.citation.titleRevista Portuguesa de Cardiologia
oaire.citation.volume43
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Clinical outcomes of percutaneous coronary intervention in chronic total occlusion in patients with type 2 diabetes mellitus.pdf
Size:
669.87 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.46 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ULS_10.1-MED-Artigos