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Gastric mixed neuroendocrine/non-neuroendocrine neoplasia: a rare entity

2023Letter to the editor Open access
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dc.contributor.authorCosta, José Damasceno e
dc.contributor.authorCosta, Rita Seara
dc.contributor.authorMoreira, Hélder Deveza
dc.contributor.authorFerreira, Aníbal
dc.date.accessioned2025-03-13T11:02:27Z
dc.date.available2025-03-13T11:02:27Z
dc.date.issued2023
dc.description.abstractGastric neoplasms have different histological subtypes. Mixed neuroendocrine/non neuroendocrine neoplasms (MiNEN), as defined by the World Health Organization (WHO) 2019 Classification of Tumours of the Digestive System, are rare composite tumours bearing morphological characteristics of more than one histological type. Historically, the diagnosis requires that each component accounts for at least 30% of the total tumour burden. We present the case of a 70-year-old male, who was referred to our endoscopy unit for resection of a depressed lesion (Paris classification type 0 IIc) of 40mm in largest diameter, located on the lesser curvature of the gastric body. The lesion was submitted to en bloc resection by endoscopic submucosal dissection. Histological examination revealed a poorly differentiated intramucosal adenocarcinoma and a grade G3 well differentiated neuroendocrine tumour (NET), on a background of chronic atrophic gastritis. Unfortunately, examination of the NET component revealed intercepted margins. The patient is currently undergoing tumour staging and will be discussed by a multidisciplinary team to determine subsequent management.eng
dc.identifier.doi10.17235/reed.2023.9988/2023
dc.identifier.issn1130-0108
dc.identifier.urihttp://hdl.handle.net/10400.1/26902
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSociedad Espanola de Patologia Digestiva (SEPD)
dc.relation.hasversionhttps://www.reed.es/ArticuloFicha.aspx?id=13355&hst=0&idR=126&tp=1
dc.relation.ispartofRevista Española de Enfermedades Digestivas
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMixed neuroendocrine/non-neuroendocrine neoplasia
dc.subjectMixed neuroendocrine/nonneuroendocrine neoplasms
dc.subjectGastric cancer
dc.titleGastric mixed neuroendocrine/non-neuroendocrine neoplasia: a rare entityeng
dc.typeletter to the editor
dspace.entity.typePublication
oaire.citation.endPage670
oaire.citation.issue11
oaire.citation.startPage670
oaire.citation.titleRevista Española de Enfermedades Digestivas
oaire.citation.volume115
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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