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Amyloid-negative, neurodegeneration-negative amnestic mild cognitive impairment

2024-08-17Journal article Open access
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dc.contributor.authorCardoso, Sandra
dc.contributor.authorGuerreiro, Manuela
dc.contributor.authorMontalvo, Alexandre
dc.contributor.authorSilva, Dina
dc.contributor.authorAlves, Luísa
dc.contributor.authorMendonça, Alexandre de
dc.date.accessioned2025-02-08T10:33:48Z
dc.date.available2025-02-08T10:33:48Z
dc.date.issued2024-08-17
dc.description.abstractBackground:The concept of amnestic mild cognitive impairment (aMCI) was developed to identify patients at an initial stage of Alzheimer's disease (AD). However, some patients with aMCI do not present biomarkers of amyloid pathology or neuronal injury.Objective:To know the natural history of amyloid-negative and neurodegeneration-negative patients with aMCI, namely to ascertain: 1) whether these patients remain cognitively stable or they present a slow decline in neuropsychological tests; 2) whether the memory complaints subside with the apparently benign clinical course of the disorder or if they persist along the time.Methods:Patients who fulfilled criteria for aMCI with no biomarkers of amyloid pathology or neuronal injury were selected from a large cohort of non-demented patients with cognitive complaints, and were followed with clinical and neuropsychological assessments.Results:Twenty-one amyloid-negative and neurodegeneration-negative aMCI patients were followed for 7.1 +/- 3.7 years. At the baseline they had more pronounced deficits in verbal learning (California Verbal Learning Test) and were also impaired in Word Recall and Logical Memory. However, they did not decline in any cognitive test during follow-up. The patients maintained a high level of subjective memory complaints from baseline (9.7 +/- 4.1) to the follow-up visit (9.2 +/- 4.1, a non-significant difference), in spite of a statistically significant decrease in the depressive symptoms, with Geriatric Depression Scale (15 items) score 4.9 +/- 2.8 at baseline and 3.2 +/- 1.8 at the follow-up visit. Conclusions: Amyloid-negative, neurodegeneration-negative aMCI is a chronic clinical condition characterized by the long-term persistence of cognitive deficits and distressing memory complaints. Adequate strategies to treat this condition are needed.eng
dc.identifier.doi10.3233/jad-240621
dc.identifier.eissn1875-8908
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/10400.1/26764
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSAGE Publications
dc.relation.ispartofJournal of Alzheimer’s Disease
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleAmyloid-negative, neurodegeneration-negative amnestic mild cognitive impairmenteng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage377
oaire.citation.issue1
oaire.citation.startPage369
oaire.citation.titleJournal of Alzheimers Disease
oaire.citation.volume101
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSilva
person.givenNameDina
person.identifier.orcid0000-0003-4437-2765
person.identifier.scopus-author-id26657734400
relation.isAuthorOfPublicationadb36ab3-1d97-48a3-b8df-544bef7c7aa0
relation.isAuthorOfPublication.latestForDiscoveryadb36ab3-1d97-48a3-b8df-544bef7c7aa0

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