Repository logo
 
Publication

Resistin as a predictor of cardiovascular hospital admissions and renal deterioration in diabetic patients with chronic kidney disease

2019-11Journal article Restricted access
Simple item page
dc.contributor.authorBonito, Bruno
dc.contributor.authorSilva, Ana Paula
dc.contributor.authorRato, FĂĄtima
dc.contributor.authorSantos, NĂ©lio
dc.contributor.authorNeves, Pedro LeĂŁo
dc.date.accessioned2020-07-24T10:51:02Z
dc.date.available2020-07-24T10:51:02Z
dc.date.issued2019-11
dc.description.abstractBackground: High resistin levels have been associated with cardiovascular disease (CVD). Cardiovascular hospitalizations are common, especially in diabetic and renal impaired patients. The purpose of this study is to determine the role of serum resistin as a predictor of cardiovascular hospitalizations in type 2 diabetic patients with mild to moderate chronic kidney disease (CKD). Methods: We conducted a prospective, observational study. 78 diabetic patients with mild to moderate CKD and no previous CVD were included. The population was divided in two groups: G-1 with cardiovascular related admission (n = 13) and G-2 without cardiovascular related admission (n = 65). A Student's t-test was conducted to determine correlations between laboratory findings and hospitalization. We used logistic regression to assess predictors of cardiovascular events requiring hospitalization and Cox regression to identify predictors of end-stage renal disease (ESRD). Results: eGFR, albumin, HbA1c, phosphorous, PTH, IR, CRP, resistin and active vitamin D, were related to cardiovascular admissions. In a multivariate regression model, resistin (OR = 2.074, p = 0.047) was an independent predictor of cardiovascular hospitalization. Cox regression showed that resistin (HR = 1.931, p = 0.031) and UACr (HR = 1.151, p = 0.048) were also independent predictors of renal disease progression. Conclusion: Resistin demonstrated to be valuable in predicting hospital admissions and progression to ESRD. (C) 2019 Elsevier Inc. All rights reserved.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.jdiacomp.2019.107422
dc.identifier.issn1056-8727
dc.identifier.urihttp://hdl.handle.net/10400.1/14188
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectCoronary-heart-disease
dc.subjectInsulin-resistance
dc.subjectInflammation
dc.subjectHypertrophy
dc.subjectAssociation
dc.subjectEvents
dc.subjectType 2 diabetes
dc.subjectResistin
dc.subjectCVD
dc.subjectCKD
dc.subjectESRD
dc.titleResistin as a predictor of cardiovascular hospital admissions and renal deterioration in diabetic patients with chronic kidney disease
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11
oaire.citation.startPageUNSP 107422
oaire.citation.titleJournal of Diabetes and its Complications
oaire.citation.volume33
person.familyNameNeves
person.givenNamePedro LeĂŁo
person.identifier.ciencia-id1014-3EA2-C680
person.identifier.orcid0000-0002-8463-0768
person.identifier.scopus-author-id7003907170
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication788c02e9-1087-4e30-8a34-5379261fc739
relation.isAuthorOfPublication.latestForDiscovery788c02e9-1087-4e30-8a34-5379261fc739

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
1-s2.0-S1056872719305173-main.pdf
Size:
202.79 KB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)
ULS2-Artigos (em revistas ou actas indexadas)