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Histamine stimulates neurogenesis in the rodent subventricular zone

2012-04Journal article Open access
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dc.contributor.authorBernardino, Liliana
dc.contributor.authorEiriz, Maria Francisca
dc.contributor.authorSantos, Tiago
dc.contributor.authorXapelli, Sara
dc.contributor.authorGrade, Sofia
dc.contributor.authorRosa, Alexandra Isabel
dc.contributor.authorCortes, Luisa
dc.contributor.authorFerreira, Raquel
dc.contributor.authorBragança, José
dc.contributor.authorAgasse, Fabienne
dc.contributor.authorFerreira, Lino
dc.contributor.authorMalva, Joao O.
dc.date.accessioned2018-12-07T14:52:31Z
dc.date.available2018-12-07T14:52:31Z
dc.date.issued2012-04
dc.description.abstractNeural stem/progenitor cells present in the subventricular zone (SVZ) are a potential source of repairing cells after injury. Therefore, the identification of novel players that modulate neural stem cells differentiation can have a huge impact in stem cell-based therapies. Herein, we describe a unique role of histamine in inducing functional neuronal differentiation from cultured mouse SVZ stem/progenitor cells. This proneurogenic effect depends on histamine 1 receptor activation and involves epigenetic modifications and increased expression of Mash1, Dlx2, and Ngn1 genes. Biocompatible poly (lactic-co-glycolic acid) microparticles, engineered to release histamine in a controlled and prolonged manner, also triggered robust neuronal differentiation in vitro. Preconditioning with histamine-loaded microparticles facilitated neuronal differentiation of SVZ-GFP cells grafted in hippocampal slices and in in vivo rodent brain. We propose that neuronal commitment triggered by histamine per se or released from biomaterial-derived vehicles may represent a new tool for brain repair strategies. STEM CELLS 2012; 30:773784
dc.description.sponsorshipFundacao para a Ciencia e a Tecnologia-Portugal [SFRH/BD/42848/2008, SFRH/BPD/34841/2007, PTDC/SAU-NEU/104415/2008, PTDC/SAU-NEU/101783/2008, PTDC/CTM/099659/2008]; Fundacao Calouste Gulbenkian [96542]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1002/stem.1042
dc.identifier.issn1066-5099
dc.identifier.urihttp://hdl.handle.net/10400.1/11105
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley-Blackwell
dc.relationHISTAMINE VERSUS ANTIHISTAMINES: NEW MODULATORS OF NEUROGENESIS
dc.relationHistamine versus antihistamines: new modulators of neurogenesis?
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEmbryonic Stem-Cells
dc.subjectNecrosis-Factor-Alpha
dc.subjectNeuronal differentiation
dc.subjectCsf histamine
dc.subjectPrecolumn derivatization
dc.subjectPromotes neurogenesis
dc.subjectTele-Methylhistamine
dc.subjectCerebrospinal-fluid
dc.subjectProgenitor cells
dc.subjectBrain
dc.titleHistamine stimulates neurogenesis in the rodent subventricular zone
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHISTAMINE VERSUS ANTIHISTAMINES: NEW MODULATORS OF NEUROGENESIS
oaire.awardTitleHistamine versus antihistamines: new modulators of neurogenesis?
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F42848%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F34841%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-NEU%2F104415%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FCTM%2F099659%2F2008/PT
oaire.citation.endPage784
oaire.citation.issue4
oaire.citation.startPage773
oaire.citation.titleAdvances in stem cells
oaire.citation.volume30
oaire.fundingStreamSFRH
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
person.familyNameBragança
person.givenNameJosé
person.identifier.ciencia-idAC1D-FA9D-F66F
person.identifier.orcid0000-0001-9566-400X
person.identifier.scopus-author-id6602220001
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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