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Newly described entities in salivary gland pathology

2017-08Journal article Restricted access
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dc.contributor.authorSkalova, Alena
dc.contributor.authorGnepp, Douglas R.
dc.contributor.authorLewis, James S., Jr.
dc.contributor.authorHunt, Jennifer L.
dc.contributor.authorBishop, Justin A.
dc.contributor.authorHellquist, Henrik
dc.contributor.authorRinaldo, Alessandra
dc.contributor.authorPoorten, Vincent Vander
dc.contributor.authorFerlito, Alfio
dc.date.accessioned2019-11-20T15:07:28Z
dc.date.available2019-11-20T15:07:28Z
dc.date.issued2017-08
dc.description.abstractSalivary glands may give rise to a wide spectrum of different tumors. This review concentrates on 4 salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma, cribriform adenocarcinoma of minor salivary glands (CASG), sclerosing polycystic adenosis/adenoma (SPA), and the mucinous/secretory variant of myoepithelioma. Mammary analog secretory carcinoma is a distinctive low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25), resulting in an ETV6-NTRK3 fusion. Cribriform adenocarcinoma (CASG) is a distinct tumor entity that differs from polymorphous low-grade adenocarcinoma by location (ie, most often arising on the tongue), by prominent nuclear clearing, differing alterations of the PRKD gene family, and clinical behavior with frequent metastases at the time of presentation of the primary tumor. Early nodal metastatic disease is seen in most cases of CASG; yet, they are still associated with indolent clinical behavior, making it a unique neoplasm among all low-grade salivary gland tumors. SPA is a rare sclerosing tumor of the salivary glands characterized by the combination of cystic ductal structures with variable cell lining including vacuolated, apocrine, mucinous, squamous, and foamy cells, by prominent large acinar cells with coarse eosinophilic cytoplasmic zymogen-like granules, and by closely packed ductal structures, surrounded by a peripheral myoepithelial layer and stromal fibrosis with focal inflammatory infiltrates. SPA frequently harbors intraductal epithelial dysplastic proliferations ranging from mild dysplasia to severe dysplasia/carcinoma in situ. Moreover, SPA has been proven to be a clonal process by HUMARA assay and is associated with considerable risk of recurrence. Therefore, on the basis of all these newly recognized findings, we believe that SPA is likely a neoplasm, and we suggest the name sclerosing polycystic adenoma. The mucinous variant of myoepithelioma is a myoepithelial tumor with foci of prominent cytoplasmic clearing frequently containing intracellular mucin material and having signet-ring morphology.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1097/PAS.0000000000000883
dc.identifier.issn0147-5185
dc.identifier.issn1532-0979
dc.identifier.urihttp://hdl.handle.net/10400.1/13058
dc.language.isoeng
dc.peerreviewedyes
dc.publisherLippincott Williams & Wilkins
dc.subjectAnalog secretory carcinoma
dc.subjectSclerosing polycystic adenosis
dc.subjectEtv6-Ntrk3 gene fusion
dc.subjectAcinic cell-carcinoma
dc.subjectCribriform adenocarcinoma
dc.subjectParotid-gland
dc.subjectCongenital fibrosarcoma
dc.subjectIn-Situ
dc.subjectRearrangement
dc.subjectCytology
dc.titleNewly described entities in salivary gland pathology
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPageE47
oaire.citation.issue8
oaire.citation.startPageE33
oaire.citation.titleAmerican Journal of Surgical Pathology
oaire.citation.volume41
person.familyNameHellquist
person.givenNameHenrik
person.identifier.ciencia-id9C11-221B-93BF
person.identifier.orcid0000-0003-3044-6065
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicatione632b82a-cf09-4f9a-b445-9d9a9de47438
relation.isAuthorOfPublication.latestForDiscoverye632b82a-cf09-4f9a-b445-9d9a9de47438

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