Salivary acinic cell carcinoma: reappraisal and update

Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.

Palavras-chave

Acinic cell carcinoma Pathology Salivary glands Therapy

URI

http://hdl.handle.net/10400.1/9231

Editora

Springer

DOI

10.1007/s00405-015-3855-7

Coleções

FCB2-Artigos (em revistas ou actas indexadas)

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