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Determinants of HIV late presentation among men who have sex with men in Portugal (2014–2019): who’s being left behind?

2024-02-29Journal article Open access
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dc.contributor.authorAbrantes, Ricardo
dc.contributor.authorPimentel, Victor
dc.contributor.authorMiranda, Mafalda N. S.
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorDiniz, António
dc.contributor.authorAscenção, Bianca
dc.contributor.authorPiñeiro, Carmela
dc.contributor.authorKoch, Carmo
dc.contributor.authorRodrigues, Catarina
dc.contributor.authorCaldas, Cátia
dc.contributor.authorMorais, Célia
dc.contributor.authorFaria, Domitília
dc.contributor.authorSilva, Elisabete Gomes da
dc.contributor.authorTeófilo, Eugénio
dc.contributor.authorMonteiro, Fátima
dc.contributor.authorRoxo, Fausto
dc.contributor.authorMaltez, Fernando
dc.contributor.authorRodrigues, Fernando
dc.contributor.authorGaião, Guilhermina
dc.contributor.authorRamos, Helena
dc.contributor.authorCosta, Inês
dc.contributor.authorGermano, Isabel
dc.contributor.authorSimões, Joana
dc.contributor.authorOliveira, Joaquim
dc.contributor.authorFerreira, José
dc.contributor.authorPoças, José
dc.contributor.authorCunha, José Saraiva da
dc.contributor.authorSoares, Jorge
dc.contributor.authorFernandes, Sandra
dc.contributor.authorMansinho, Kamal
dc.contributor.authorPedro, Liliana
dc.contributor.authorAleixo, Maria João
dc.contributor.authorGonçalves, Maria João
dc.contributor.authorManata, Maria José
dc.contributor.authorMouro, Margarida
dc.contributor.authorSerrado, Margarida
dc.contributor.authorCaixeiro, Micaela
dc.contributor.authorMarques, Nuno
dc.contributor.authorCosta, Olga
dc.contributor.authorPacheco, Patrícia
dc.contributor.authorProença, Paula
dc.contributor.authorRodrigues, Paulo
dc.contributor.authorPinho, Raquel
dc.contributor.authorTavares, Raquel
dc.contributor.authorAbreu, Ricardo Correia de
dc.contributor.authorCôrte-Real, Rita
dc.contributor.authorSerrão, Rosário
dc.contributor.authorCastro, Rui Sarmento e
dc.contributor.authorNunes, Sofia
dc.contributor.authorFaria, Telo
dc.contributor.authorBaptista, Teresa
dc.contributor.authorSimões, Daniel
dc.contributor.authorMendão, Luis
dc.contributor.authorMartins, M. Rosário O.
dc.contributor.authorGomes, Perpétua
dc.contributor.authorPingarilho, Marta
dc.contributor.authorAbecasis, Ana B.
dc.date.accessioned2024-12-06T11:18:55Z
dc.date.available2024-12-06T11:18:55Z
dc.date.issued2024-02-29
dc.description.abstractIntroduction HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with late presentation in the MSM population newly diagnosed with HIV in Portugal between 2014 and 2019.Methods We included 391 newly HIV-1 diagnosed Men who have Sex with Men (MSM), from the BESTHOPE project, in 17 countrywide Portuguese hospitals. The data included clinical and socio-behavioral questionnaires and the viral genomic sequence obtained in the drug resistance test before starting antiretrovirals (ARVs). HIV-1 subtypes and epidemiological surveillance mutations were determined using different bioinformatics tools. Logistic regression was used to estimate the association between predictor variables and late presentation (LP).Results The median age was 31 years, 51% had a current income between 501-1,000 euros, 28% were migrants. 21% had never been tested for HIV before diagnosis, with 42.3% of MSM presenting LP. 60% were infected with subtype B strains. In the multivariate regression, increased age at diagnosis, higher income, lower frequency of screening, STI ever diagnosed and higher viral load were associated with LP.Conclusion Our study suggests that specific subgroups of the MSM population, such older MSM, with higher income and lower HIV testing frequency, are not being targeted by community and clinical screening services. Overall, targeted public health measures should be strengthened toward these subgroups, through strengthened primary care testing, expanded access to PrEP, information and promotion of HIV self-testing and more inclusive and accessible health services.eng
dc.description.sponsorshipUID/04413/2020; PTDC/DTP-EPI/7066/2014; Multi/04413/2013; PTDC/SAUINF/31990/2017; PTDC/SAU-PUB/4018/2021
dc.identifier.doi10.3389/fpubh.2024.1336845
dc.identifier.issn2296-2565
dc.identifier.urihttp://hdl.handle.net/10400.1/26408
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relationGlobal Health and Tropical Medicine
dc.relationTranslation and Innovation towards Global Health
dc.relation.hasversionhttps://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1336845/full
dc.relation.ispartofFrontiers in Public Health
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHIV-1
dc.subjectPortugal
dc.subjectDrug resistance
dc.subjectLate presentation
dc.subjectMen who have sex with men
dc.subjectVulnerable populations
dc.titleDeterminants of HIV late presentation among men who have sex with men in Portugal (2014–2019): who’s being left behind?eng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleGlobal Health and Tropical Medicine
oaire.awardTitleTranslation and Innovation towards Global Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04413%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0117%2F2020/PT
oaire.citation.endPage16
oaire.citation.startPage1
oaire.citation.titleFrontiers in Public Health
oaire.citation.volume12
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication5a7a17ef-fb7b-49e5-b474-9c4ae38fc4f4
relation.isProjectOfPublication0774ac57-0b7c-4a2f-a6c1-aebbfba71c27
relation.isProjectOfPublication.latestForDiscovery5a7a17ef-fb7b-49e5-b474-9c4ae38fc4f4

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