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Neutralization-based seroprevalence of Toscana virus and sandfly fever Sicilian virus in dogs and cats from Portugal

2016-07Journal article Restricted
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dc.contributor.authorAlwassouf, Sulaf
dc.contributor.authorMaia, Carla
dc.contributor.authorAyhan, Nazli
dc.contributor.authorCoimbra, Mónica
dc.contributor.authorCristovão, José Manuel
dc.contributor.authorRichet, Herve
dc.contributor.authorBichaud, Laurence
dc.contributor.authorCampino, Lenea
dc.contributor.authorCharrel, Remi N.
dc.date.accessioned2017-04-07T15:55:47Z
dc.date.available2017-04-07T15:55:47Z
dc.date.issued2016-07
dc.description.abstractSandfly-borne phleboviruses are endemic in the Mediterranean basin. However, levels of exposure of human and animal populations are inadequately researched. Toscana virus (TOSV) is present in Portugal where it causes human infection and disease; in contrast there are few data for sandfly fever Sicilian virus (SFSV) which has neither been isolated nor detected by molecular tests and for which there are only limited serological data. The sera collected from 1160 dogs and 189 cats in southern Portugal were tested for the presence of neutralizing antibodies against TOSV and SFSV, two viruses recognized as distinct serocomplexes in the Mediterranean region. Our data showed (i) seropositivity to TOSV and SFSV in dogs at a rate of 6.8 and 50.8 %, respectively, and (ii) that 3.7 % of cats were seropositive for TOSV. TOSV findings are in line with previous results obtained with less stringent serological assays. Our results for SFSV in dogs clearly indicate that the virus is circulating widely and that humans may be exposed to infection via the dogs. Although the presence of SFSV was suggested by haemagglutination inhibition in 4/1690 human sera in 1974, this is the first time, as far as we know, that SFSV has been shown to circulate so widely in dogs in Portugal. Future studies should be directed at isolating strains of SFSV in Portugal from dogs, humans and sandflies collected in high prevalence regions. As dogs appear to be good sentinels for SFSV, their role as a possible reservoir in the natural cycle should also be considered.
dc.description.sponsorshipGrant FP7-261504
dc.identifier.doi10.1099/jgv.0.000592
dc.identifier.issn0022-1317
dc.identifier.otherAUT: LMC02419
dc.identifier.urihttp://hdl.handle.net/10400.1/9221
dc.language.isoeng
dc.peerreviewedyes
dc.relationEuropean Virus Archive goes global
dc.relation.isbasedonWOS:000388677600003
dc.titleNeutralization-based seroprevalence of Toscana virus and sandfly fever Sicilian virus in dogs and cats from Portugal
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Virus Archive goes global
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04413%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01302%2F2015%2FCP1320%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/653316/EU
oaire.citation.endPage2823
oaire.citation.startPage2816
oaire.citation.titleJournal of General Virology
oaire.citation.volume97
oaire.fundingStream5876
oaire.fundingStreamInvestigador FCT
oaire.fundingStreamH2020
person.familyNameCampino
person.givenNameLenea
person.identifier.ciencia-id2A16-58CC-48FE
person.identifier.orcid0000-0003-4512-9660
person.identifier.scopus-author-id6603808132
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscovery408b2ada-2070-4192-8710-aebcd7eba09a
relation.isProjectOfPublication2ee7a2ab-a31a-4851-82de-5e3497bc92e4
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