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Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles

2017-09Journal article Restricted access
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dc.contributor.authorSantos, Tiago
dc.contributor.authorFerreira, Raquel
dc.contributor.authorQuartin, Emanuel
dc.contributor.authorBoto, Carlos
dc.contributor.authorSaraiva, Claudia
dc.contributor.authorBragança, José
dc.contributor.authorPeca, Joao
dc.contributor.authorRodrigues, Cecilia
dc.contributor.authorFerreira, Lino
dc.contributor.authorBernardino, Liliana
dc.date.accessioned2019-11-20T15:07:24Z
dc.date.available2019-11-20T15:07:24Z
dc.date.issued2017-09
dc.description.abstractNeurogenic niches constitute a powerful endogenous source of new neurons that can be used for brain repair strategies. Neuronal differentiation of these cells can be regulated by molecules such as retinoic acid (RA) or by mild levels of reactive oxygen species (ROS) that are also known to upregulate RA receptor alpha (RAR alpha) levels. Data showed that neural stem cells from the subventricular zone (SVZ) exposed to blue light (405 nm laser) transiently induced NADPH oxidase-dependent ROS, resulting in beta-catenin activation and neuronal differentiation, and increased RAR alpha levels. Additionally, the same blue light stimulation was capable of triggering the release of RA from light-responsive nanoparticles (LR-NP). The synergy between blue light and LR-NP led to amplified neurogenesis both in vitro and in vivo, while offering a temporal and spatial control of RA release. In conclusion, this combinatory treatment offers great advantages to potentiate neuronal differentiation, and provides an innovative and efficient application for brain regenerative therapies. Statement of Significance Controlling the differentiation of stem cells would support the development of promising brain regenerative therapies. Blue light transiently increased reactive oxygen species, resulting in neuronal differentiation and increased retinoic acid receptor (RAR alpha) levels. Additionally, the same blue light stimulation was capable of triggering the release of RA from light-responsive nanoparticles (LR-NP). The synergy between blue light and LR-NP led to amplified neurogenesis, while offering a temporal and spatial control of RA release. In this sense, our approach relying on the modulation of endogenous stem cells for the generation of new neurons may support the development of novel clinical therapies. (C) 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
dc.description.sponsorshipFEDER [FCOMP-01-0124-FEDER-041099, POCI-COMPETE2020]
dc.description.sponsorshipCOMPETE [BD/79526/2011, Centro-07-ST24-FEDER-002008]
dc.description.sponsorshipL'Oreal-UNESCO Portugal for Women in Science
dc.description.sponsorshipProfessor Francisco Pulido Valente Foundation, EC [ERC 307384]
dc.description.sponsorshipOperational Programme Competitiveness and Internationalization in Axis-I [007491]
dc.description.sponsorshipFCT [Project UID/Multi/00709]
dc.identifier.doi10.1016/j.actbio.2017.06.044
dc.identifier.issn1742-7061
dc.identifier.issn1878-7568
dc.identifier.urihttp://hdl.handle.net/10400.1/13019
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier Sci Ltd
dc.relationHistamine versus antihistamines: new modulators of neurogenesis?
dc.subjectNeural stem-cells
dc.subjectCentral-nervous-system
dc.subjectSubventricular zone
dc.subjectAdult neurogenesis
dc.subjectWnt/Beta-catenin
dc.subjectNadph oxidases
dc.subjectGtpase rac1
dc.subjectBrain
dc.subjectDifferentiation
dc.subjectActivation
dc.titleBlue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHistamine versus antihistamines: new modulators of neurogenesis?
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-NEU%2F104415%2F2008/PT
oaire.citation.endPage302
oaire.citation.startPage293
oaire.citation.titleActa Biomaterialia
oaire.citation.volume59
oaire.fundingStream5876-PPCDTI
person.familyNameBragança
person.givenNameJosé
person.identifier.ciencia-idAC1D-FA9D-F66F
person.identifier.orcid0000-0001-9566-400X
person.identifier.scopus-author-id6602220001
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscovery27334e02-e955-4939-b9b5-bdee5b5f9328
relation.isProjectOfPublication7d1a83cf-d7e7-4e43-9c2c-9986c50b6bc5
relation.isProjectOfPublication.latestForDiscovery7d1a83cf-d7e7-4e43-9c2c-9986c50b6bc5

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