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Mechanisms of vertebrate embryo segmentation: Common themes in trunk and limb development

2016-07Journal article Restricted
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dc.contributor.authorSheeba, C.J.
dc.contributor.authorAndrade, Raquel P.
dc.contributor.authorPalmeirim, Isabel
dc.date.accessioned2017-04-07T15:57:37Z
dc.date.available2017-04-07T15:57:37Z
dc.date.issued2016-07
dc.description.abstractVarious ultradian rhythms ensure proper temporal regulations during embryo development. The embryo molecular clock, which was first identified in the presomitic mesoderm (PSM) underlying periodic somite formation, is one among them. Somites are the earliest manifestation of the segmented vertebrate body and they are formed with strict temporal precision. The tetrapod limb is also a segmented structure and the formation of limb bone elements have also been associated with a molecular clock, operating in the distal limb mesenchyme. In both the PSM and the distal limb mesenchyme, the molecular clock (MC) is influenced by FGF, SHH and RA, which are also the key regulators of the development of these tissues. While somitogenesis has been continuously scrutinized to understand the mechanisms of the MC, the limb bud has served as an outstanding paradigm to study how a cohort of undifferentiated cells is organized into functional 3D structures. The fact that both the trunk and limb development are shaped by the MC and by common signaling molecules has prompted the exciting possibility of establishing parallelisms between somitogenesis and limb development. Systematically correlating various parameters during trunk and limb development will help us to appreciate the common principles underlying segmented structure formation and allow the rise of new questions in order to fill the gaps in our present understanding. In this review we have established the parallelisms between somitogenesis and limb development at the level of gene expression patterns and their regulation. Finally, we have also discussed the most evident new avenues this exercise could open to the scientific community. (C) 2016 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.semcdb.2016.01.010
dc.identifier.issn1084-9521
dc.identifier.otherAUT: IME02311;
dc.identifier.urihttp://hdl.handle.net/10400.1/9767
dc.language.isoeng
dc.peerreviewedyes
dc.relationSHEDDING LIGHT ON THE CONTROVERSY: ESTABLISHING THE EMBRYO MOLECULAR CLOCK AS AN INTEGRAL COMPONENT OF THE LIMB PATTERNING MACHINERY
dc.relationhuman Mesenchymal Stem Cells Chronobiology: evaluating the crosstalk between the Embryonic and Circadian Clocks
dc.relationTIMING CELL DIFFERENTIATON: Gene Regulatory Network in Temporal Control of Mesoderm Specification
dc.relation.isbasedonWOS:000370643900018
dc.titleMechanisms of vertebrate embryo segmentation: Common themes in trunk and limb development
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSHEDDING LIGHT ON THE CONTROVERSY: ESTABLISHING THE EMBRYO MOLECULAR CLOCK AS AN INTEGRAL COMPONENT OF THE LIMB PATTERNING MACHINERY
oaire.awardTitlehuman Mesenchymal Stem Cells Chronobiology: evaluating the crosstalk between the Embryonic and Circadian Clocks
oaire.awardTitleTIMING CELL DIFFERENTIATON: Gene Regulatory Network in Temporal Control of Mesoderm Specification
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F89493%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-MED%2F1063%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBEX-BID%2F5410%2F2014/PT
oaire.citation.endPage134
oaire.citation.startPage125
oaire.citation.titleSeminars in Cell and Developmental Biology
oaire.citation.volume49
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
person.familyNameSheeba
person.familyNameAndrade
person.familyNamePalmeirim
person.givenNameCaroline Jeya
person.givenNameRaquel
person.givenNameIsabel
person.identifier437977
person.identifier.ciencia-id2312-360B-227A
person.identifier.ciencia-id141A-4DE2-6FF3
person.identifier.orcid0000-0001-5357-4743
person.identifier.orcid0000-0002-0397-5917
person.identifier.orcid0000-0003-2282-7829
person.identifier.ridB-5177-2011
person.identifier.scopus-author-id6504257550
person.identifier.scopus-author-id7103114918
person.identifier.scopus-author-id6603305227
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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