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Comparative expression of mouse and chicken shisa homologues during early development

2006-09Journal article Open access
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dc.contributor.authorFilipe, Mario
dc.contributor.authorGonçalves Dias da Silva, Lisa
dc.contributor.authorBento, Margaret
dc.contributor.authorSilva, Ana Cristina
dc.contributor.authorBelo, José A.
dc.date.accessioned2018-12-07T14:58:14Z
dc.date.available2018-12-07T14:58:14Z
dc.date.issued2006-09
dc.description.abstractDuring vertebrate embryogenesis, fibroblast growth factor (FGF) and Wnt signaling have been implicated in diverse cellular processes, including cell growth, differentiation, and tissue patterning. The recently identified Xenopus Shisa protein promotes head formation by inhibiting Wnt and FGF signaling through its interaction with the immature forms of Frizzled and FGF receptors in the endoplasmic reticulum, which prevents their posttranslational maturation. Here, we describe the mouse and chicken homologues of Xenopus Shisa. The mouse and chicken Shisa proteins share, respectively, 33.6% and 33.8% identity with the Xenopus homolog. In situ hybridization analysis shows that mouse shisa is expressed throughout embryonic development, predominantly in the anterior visceral endoderm, headfolds, somites, forebrain, optic vesicle, and limb buds. Cross-species comparison shows that the expression pattern of cshisa closely mirrors that of mshisa. Our observations indicate that the Shisa family genes are typically expressed in tissues known to require the modulation of Wnt and FGF signaling. Developmental Dynamics 235:2567-2573, 2006. (c) 2006 Wiley-Liss, Inc.
dc.identifier.doi10.1002/dvdy.20862
dc.identifier.issn1058-8388
dc.identifier.urihttp://hdl.handle.net/10400.1/11924
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley-Liss
dc.subjectAnterior primitive endoderm
dc.subjectVisceral endoderm
dc.subjectHead induction
dc.subjectCell migration
dc.subjectIn-Vitro
dc.subjectEmbryo
dc.subjectSomite
dc.subjectMyogenesis
dc.subjectAxis
dc.subjectWnt
dc.titleComparative expression of mouse and chicken shisa homologues during early development
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2573
oaire.citation.issue9
oaire.citation.startPage2567
oaire.citation.titleDevelopmental Dynamics
oaire.citation.volume235
person.familyNameGonçalves Dias da Silva
person.familyNameBento Soares
person.familyNameBelo
person.givenNameLisa
person.givenNameMargaret
person.givenNameJosé A.
person.identifier.ciencia-idD914-5A0B-3F42
person.identifier.ciencia-idBF13-08E9-25E6
person.identifier.orcid0000-0002-3431-5217
person.identifier.orcid0000-0001-7384-0949
person.identifier.ridF-4444-2012
person.identifier.scopus-author-id14421240100
person.identifier.scopus-author-id6602141392
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication6cc4141c-3a50-4075-9b9b-903bb54ffb67
relation.isAuthorOfPublication324dfd05-0e6e-427f-8712-761359e046a9
relation.isAuthorOfPublication4bebeb48-6fac-41a9-8363-f849def5e019
relation.isAuthorOfPublication.latestForDiscovery4bebeb48-6fac-41a9-8363-f849def5e019

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