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Comparing the continuous geboes score with the Robarts Histopathology Index: definitions of histological remission and response and their relation to faecal calprotectin levels

2020-02Journal article Restricted access
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dc.contributor.authorMagro, Fernando
dc.contributor.authorLopes, Joanne
dc.contributor.authorBorralho, Paula
dc.contributor.authorLopes, Susana
dc.contributor.authorCoelho, Rosa
dc.contributor.authorCotter, Jose
dc.contributor.authorde Castro, Francisca Dias
dc.contributor.authorSousa, Helena Tavares
dc.contributor.authorSalgado, Marta
dc.contributor.authorAndrade, Patricia
dc.contributor.authorVieira, Ana Isabel
dc.contributor.authorFigueiredo, Pedro
dc.contributor.authorCaldeira, Paulo
dc.contributor.authorSousa, A.
dc.contributor.authorDuarte, Maria A.
dc.contributor.authorAvila, Filipa
dc.contributor.authorSilva, Joao
dc.contributor.authorMoleiro, Joana
dc.contributor.authorMendes, Sofia
dc.contributor.authorGiestas, Silvia
dc.contributor.authorMinistro, Paula
dc.contributor.authorSousa, Paula
dc.contributor.authorGoncalves, Raquel
dc.contributor.authorGoncalves, Bruno
dc.contributor.authorOliveira, Ana
dc.contributor.authorChagas, Cristina
dc.contributor.authorCravo, Marilia
dc.contributor.authorDias, Claudia Camila
dc.contributor.authorAfonso, Joana
dc.contributor.authorPortela, Francisco
dc.contributor.authorSantiago, Mafalda
dc.contributor.authorGeboes, Karel
dc.contributor.authorCarneiro, Fatima
dc.date.accessioned2021-06-24T11:35:57Z
dc.date.available2021-06-24T11:35:57Z
dc.date.issued2020-02
dc.description.abstractBackground and Aims: The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker and a key component of disease monitoring. Our main aims were to compare two histological indexes-the continuous Geboes score [GS] and the Robarts Histopathology index [RHI]-regarding their definitions of histological remission and response, and the ability of faecal calprotectin [FC] levels to discriminate between these statuses. Methods: This was an analysis of three prospective cohorts including 422 patients previously enrolled in other studies. Results: The two continuous scores [GS and RHI] were shown to be significantly correlated [correlation coefficient of 0.806, p < 0.001] and particularly close regarding their definition of histological response: 95% and 88% of all patients classified as having/not having [respectively] histological response according to RHI also did so according to GS. Moreover, median FC levels in patients with histological response were lower than those in patients without histological response [GS: 73.00 vs 525.00, p < 0.001; RHI: 73.50 vs 510.00, p < 0.001]; a similar trend was observed when FC levels of patients in histological remission were compared to those of patients with histological activity [GS: 76.00 vs 228.00, p < 0.001; RHI: 73.50 vs 467.00, p < 0.001]. FC levels allowed us to exclude the absence of histological remission [according to RHI] and absence of histological response [according to RHI and GS], with negative predictive values varying from 82% to 96%. However, optimization of the FC cut-off to exclude the absence of histological remission, as for the continuous GS, falls within values that resemble those of the healthy population. Conclusion: The continuous GS and RHI histological scores are strongly correlated in their definitions of histological response. An absence of histological remission could only be excluded at physiological levels of FC.
dc.description.sponsorshipPortuguese IBD group [GEDII- Grupo de Estudo da Doenca Inflamatoria Intestinal]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1093/ecco-jcc/jjz123
dc.identifier.issn1873-9946
dc.identifier.urihttp://hdl.handle.net/10400.1/16586
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.subjectEndoscopic activity
dc.subjectHistological activity
dc.subjectUlcerative colitis
dc.subject.otherGastroenterology & Hepatology
dc.titleComparing the continuous geboes score with the Robarts Histopathology Index: definitions of histological remission and response and their relation to faecal calprotectin levels
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage175
oaire.citation.issue2
oaire.citation.startPage169
oaire.citation.titleJournal of Crohns & Colitis
oaire.citation.volume14
person.familyNameSousa
person.familyNameCaldeira
person.givenNameHelena Tavares
person.givenNamePaulo
person.identifier.ciencia-idCF1F-1163-1C4A
person.identifier.ciencia-id1112-F0B2-19A3
person.identifier.orcid0000-0002-6626-205X
person.identifier.orcid0000-0002-2404-6295
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication6b1d11dd-486f-4fb3-b41f-02e1cf6a5c2e
relation.isAuthorOfPublication3def3720-8982-4c46-801d-af640d508b59
relation.isAuthorOfPublication.latestForDiscovery6b1d11dd-486f-4fb3-b41f-02e1cf6a5c2e

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