Publication
Tip lesion variant of focal and segmental glomerulosclerosis in a COVID-19 patient
| dc.contributor.author | Afonso, Rita Serra | |
| dc.contributor.author | Calças Marques, Roberto | |
| dc.contributor.author | Borges, Henrique | |
| dc.contributor.author | Carias, Eduarda | |
| dc.contributor.author | Domingos, Ana Teresa | |
| dc.contributor.author | Cabrita, Ana | |
| dc.contributor.author | Sampaio, Sandra | |
| dc.contributor.author | Silva, Ana Paula | |
| dc.date.accessioned | 2023-01-31T10:01:55Z | |
| dc.date.available | 2023-01-31T10:01:55Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Acute kidney injury is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathologic findings are continually being reported, showing a probably multifactorial etiology. The authors present a case of a patient diagnosed with a tip lesion variant of focal segmental glomerulosclerosis (FSGS) in the setting of COVID-19. A 43-year-old African American female with no known renal disease presented to the emergency department with a 6-day history of fatigue, headache, hypoageusia, myalgia, cough, nausea, and vomiting. Laboratory tests confirmed SARS-CoV-2 infection. During hospitalization, there was a progressive decline in kidney function and evidence of nephrotic-range proteinuria without nephrotic syndrome. Biopsy specimen showed a tip lesion variant of FSGS. Genetic test revealed a homozygous variant of uncertain clinical significance (c.397G>A [p.V133M]) in the epithelial membrane protein 2 (EMP2) gene. To our knowledge, this is the first case report of a tip lesion in a COVID-19 patient with no renal history. More studies are warranted to define susceptible groups and identify the detailed mechanisms of COVID-19-related kidney disease that would allow for specific management of this complication. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1159/000528029 | pt_PT |
| dc.identifier.issn | 2296-9705 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/18968 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Karger | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Acute kidney injury | pt_PT |
| dc.subject | Proteinuria | pt_PT |
| dc.subject | Renal biopsy | pt_PT |
| dc.subject | SARS-CoV-2 | pt_PT |
| dc.title | Tip lesion variant of focal and segmental glomerulosclerosis in a COVID-19 patient | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 254 | pt_PT |
| oaire.citation.issue | 3 | pt_PT |
| oaire.citation.startPage | 248 | pt_PT |
| oaire.citation.title | Case Reports in Nephrology and Dialysis | pt_PT |
| oaire.citation.volume | 12 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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