Risk factors of hip fractures in chronic kidney disease patients

Mendes, Filipa; Gomes, Ana; Alonso, Isis; Fragoso, André; Pereira, Luisa Helena; Jerónimo, Teresa; Pimentel, Ana; Neves, Pedro L.

http://hdl.handle.net/10400.1/9496

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Authors

Pereira, Luisa Helena

Jerónimo, Teresa

Pimentel, Ana

Neves, Pedro L.

Abstract(s)

In the Western World the general population is getting older. This implies a higher prevalence of osteoporosis as well as a greater incidence of patients with chronic kidney disease. These two conditions increase the riskof bone fractures. Metabolic and hormonal disarrangement in end-stage renal disease (ESRD) negativelyaffects bone remodeling as it promotes a decrease in Vitamin D availability, hyperphosphatemia, hypocalcemia, high secretion of parathormone and chronic metabolic acidosis. The NHANES III showed that even moderate-to-severe CKD patients may present with a significant increased riskoffracturewhich is justified by hyperparathyroidism at the earlystages of the disease.