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Mapping gene expression in social anxiety reveals the main brain structures involved in this disorder

2020-09-15Journal article Restricted access
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dc.contributor.authorCarvalho, Filipe Ricardo Pires de
dc.contributor.authorNóbrega, Clévio
dc.contributor.authorMartins, A.
dc.date.accessioned2021-06-24T11:35:16Z
dc.date.available2021-06-24T11:35:16Z
dc.date.issued2020-09-15
dc.description.abstractSocial Anxiety Disorder (SAD) is characterized by emotional and attentional biases as well as distorted negative self-beliefs. According this, we proposed to identify the brain structures and hub genes involved in SAD. An analysis in Pubmed and TRANSFAC was conducted and 72 genes were identified. Using Microarray data, from Allen Human Brain Atlas, it was possible to identify three modules of co-expressed genes from our gene set (R package WGCNA). Higher mean gene expression was found in cortico-medial group, basomedial nucleus, ATZ in amygdala and in head and tail of the caudate nucleus, nucleus accumbens and putamen in striatum. Our enrichment analysis identified the followed hub genes: DRD2, HTR1A, JUN, SP1 and HDAC4. We suggest that SAD is explained by delayed extinction of circuitry for conditioned fear. Caused by reduced activation of the dopaminergic and serotonergic systems,due diminished expectation of reward during social interactions.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.bbr.2020.112808
dc.identifier.issn0166-4328
dc.identifier.urihttp://hdl.handle.net/10400.1/16390
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectAnxiety
dc.subjectNeuroscience
dc.subjectReward
dc.subjectWGCNA
dc.subjectGenetics
dc.subject.otherBehavioral Sciences
dc.titleMapping gene expression in social anxiety reveals the main brain structures involved in this disorder
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage112808
oaire.citation.titleBehavioural Brain Research
oaire.citation.volume394
person.familyNamePires de Carvalho
person.familyNameNóbrega
person.familyNameMartins
person.givenNameFilipe Ricardo
person.givenNameClévio
person.givenNameAna
person.identifier1418026
person.identifier.ciencia-id181A-A440-7D6E
person.identifier.ciencia-idC510-7F41-BAF8
person.identifier.ciencia-idE113-84F0-5FB7
person.identifier.orcid0000-0002-1468-0305
person.identifier.orcid0000-0002-8312-5292
person.identifier.orcid0000-0002-3304-6051
person.identifier.ridM-6047-2013
person.identifier.scopus-author-id55115644400
person.identifier.scopus-author-id24473454000
person.identifier.scopus-author-id17344059400
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication55c2b5fb-f39a-4675-834a-f44c5fe417aa
relation.isAuthorOfPublication725ea6f8-1363-4cee-9cf2-5ac7303b3ba9
relation.isAuthorOfPublication19d5506a-b3f6-4a3f-8e9e-4a9589033f6b
relation.isAuthorOfPublication.latestForDiscovery55c2b5fb-f39a-4675-834a-f44c5fe417aa

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