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A randomized controlled trial assessing the release of circulating tumor and mesenchymal cells in no-touch radical nephrectomy

2024-10-25Journal article Open access
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg04:Educação de Qualidade
dc.contributor.authorLeitão, Tito Palmela
dc.contributor.authorCorredeira, Patrícia
dc.contributor.authorRodrigues, Carolina
dc.contributor.authorPiairo, Paulina
dc.contributor.authorMiranda, Miguel
dc.contributor.authorMartins Cavaco, Ana Cláudia
dc.contributor.authorKucharczak, Sandra
dc.contributor.authorAntunes, Marília
dc.contributor.authorPeixoto, Sara
dc.contributor.authorReis, José Palma dos
dc.contributor.authorLopes, Tomé
dc.contributor.authorDiéguez, Lorena
dc.contributor.authorCosta, Luís
dc.date.accessioned2026-01-16T13:52:55Z
dc.date.available2026-01-16T13:52:55Z
dc.date.issued2024-10-25
dc.description.abstractAbstract: Background: Circulating tumor cells (CTCs) may be the missing renal cell carcinoma (RCC) biomarker. No-touch (NT) resection has shown benefit in several tumors. Methods: A randomized controlled trial comparing CTC and circulating mesenchymal cell (CMC) release in no-touch (NT) vs. conventional (C) laparoscopic RN. Blood samples were collected at operation room arrival (S0), specimen extraction (S1), postoperative D1, and D30. CTCs were isolated and analyzed using RUBYchip™. Results: Thirty-four patients were included. No significant differences were found between groups in CTC and CMC counts, count variations between time points, complications, and survival. The total circulating cell detection rates in the NT, C, and overall RCC groups were 58.3%, 80.0%, and 70.4% at S0; 41.6%, 86.7%, and 66.7% at S1; 50.0%, 64.3%, and 60.0% at D1; and 54.5%, 42.9%, and 44.0% at D30, respectively. A progressive decrease in CMCs was observed in the C group after surgery, especially at D1 (4.78 to 1.64 CMCs/7.5 mL blood, p = 0.035). Healthy controls had no circulating cells; however, high CMC counts were found in chronic inflammation controls and oncocytoma patients, with no significant difference from RCC patients (p = 0.460). Conclusions: NT RN did not reduce circulating cell release nor improve survival compared to C RN.eng
dc.description.sponsorshipLCF/TR/CC20/52480003
dc.identifier.doi10.3390/cancers16213601
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/10400.1/28124
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationCentre of Statistics and its Applications
dc.relation.ispartofCancers
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCirculating mesenchymal cell
dc.subjectCirculating tumor cell
dc.subjectKidney cancer
dc.subjectLaparoscopy
dc.subjectLiquid biopsy
dc.subjectMicrofluidics
dc.subjectNo-touch surgery
dc.subjectRadical nephrectomy
dc.subjectRenal cell carcinoma
dc.titleA randomized controlled trial assessing the release of circulating tumor and mesenchymal cells in no-touch radical nephrectomyeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Statistics and its Applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00006%2F2020/PT
oaire.citation.issue21
oaire.citation.titleCancers
oaire.citation.volume16
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMartins Cavaco
person.givenNameAna Cláudia
person.identifier.orcid0000-0002-0642-1979
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication84ee62df-e553-44f2-9336-ab736f501793
relation.isAuthorOfPublication.latestForDiscovery84ee62df-e553-44f2-9336-ab736f501793
relation.isProjectOfPublication100e6d17-2f76-4282-b864-d0f887b34243
relation.isProjectOfPublication.latestForDiscovery100e6d17-2f76-4282-b864-d0f887b34243

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