Publication
NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic functions in Leukemic and in Microenvironmental Cells
| dc.contributor.author | Rodrigues Dos Santos, Nuno | |
| dc.contributor.author | Ghezzo, Marinella N. | |
| dc.contributor.author | Da Silva, Ricardo C. | |
| dc.contributor.author | Fernandes, Mónica T. | |
| dc.date.accessioned | 2022-10-17T13:50:12Z | |
| dc.date.available | 2022-10-17T13:50:12Z | |
| dc.date.issued | 2010-11-05 | |
| dc.date.updated | 2022-10-13T15:41:58Z | |
| dc.description.abstract | Two main NF-κB signaling pathways, canonical and noncanonical, performing distinct functions in organisms have been characterized. Identification of mutations in genes encoding components of these NF-κB signaling pathways in lymphoid malignancies confirmed their key role in leukemogenesis. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes that despite significant therapeutic advances can still be fatal. Although mutations in NF-κB genes have not been reported in T-ALL, NF-κB constitutive activation in human T-ALL and in acute T-cell leukemia mouse models has been observed. Although these studies revealed activation of members of both canonical and noncanonical NF-κB pathways in acute T-cell leukemia, only inhibition of canonical NF-κB signaling was shown to impair leukemic T cell growth. Besides playing an important pro-oncogenic role in leukemic T cells, NF-κB signaling also appears to modulate T-cell leukemogenesis through its action in microenvironmental stromal cells. This article reviews recent data on the role of these transcription factors in T-ALL and pinpoints further research crucial to determine the value of NF-κB inhibition as a means to treat T-ALL. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier | doi: 10.3390/cancers2041838 | |
| dc.identifier.citation | Cancers 2 (4): 1838-1860 (2010) | pt_PT |
| dc.identifier.issn | doi: 10.3390/cancers2041838 | |
| dc.identifier.issn | doi: 10.3390/cancers2041838 | |
| dc.identifier.issn | 2072-6694 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/18400 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | NF-B | pt_PT |
| dc.subject | Signaling | pt_PT |
| dc.subject | T cell | pt_PT |
| dc.subject | Leukemia | pt_PT |
| dc.subject | Lymphoma | pt_PT |
| dc.subject | NOTCH1 | pt_PT |
| dc.subject | Microenvironment | pt_PT |
| dc.title | NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic functions in Leukemic and in Microenvironmental Cells | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Cancers | pt_PT |
| person.familyName | Rodrigues dos Santos | |
| person.givenName | Nuno | |
| person.identifier.orcid | 0000-0001-7347-2592 | |
| person.identifier.scopus-author-id | 7006810054 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | cd54e8ca-80e4-49d1-8fa1-d275fc51ddb2 | |
| relation.isAuthorOfPublication.latestForDiscovery | cd54e8ca-80e4-49d1-8fa1-d275fc51ddb2 |