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The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis

2004-10Journal article Open access
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dc.contributor.authorMarques, Sara
dc.contributor.authorBorges, Ana
dc.contributor.authorSilva, Ana Cristina
dc.contributor.authorFreitas, Sandra
dc.contributor.authorCordenonsi, M.
dc.contributor.authorBelo, José A.
dc.date.accessioned2018-12-07T14:58:06Z
dc.date.available2018-12-07T14:58:06Z
dc.date.issued2004-10
dc.description.abstractCorrect establishment of the left/right (L/R) body asymmetry in the mouse embryo requires asymmetric activation of the evolutionarily conserved Nodal signaling cascade in the left lateral plate mesoderm (L-LPM). Furthermore, the presence of Nodal in the node is essential for its own expression in the L-LPM. Here, we have characterized the function of cerl-2, a novel Nodal antagonist, which displays a unique asymmetric expression on the right side of the mouse node. cerl-2 knockout mice display multiple laterality defects including randomization of the L/R axis. These defects can be partially rescued by removing one nodal allele. Our results demonstrate that Cerl-2 plays a key role in restricting the Nodal signaling pathway toward the left side of the mouse embryo by preventing its activity in the right side.
dc.description.sponsorshipThis work was supported byresearch grants from F.C.T. and IGC/Fundação Calouste Gulbenkian toJ.A.B.; J.A.B. is a Principal Investigator at the IGC/Fundação CalousteGulbenkian.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/ 10.1101/gad.306504
dc.identifier.issn0890-9369
dc.identifier.urihttp://hdl.handle.net/10400.1/11863
dc.language.isoeng
dc.peerreviewedyes
dc.publisherCold Spring Harbor Laboratory Press
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectLeft/right asymmetry
dc.subjectNeuralizing activity
dc.subjectSecreted factor
dc.subjectCerberus like
dc.subjectExpression
dc.subjectPitx2
dc.subjectBmp
dc.subjectLefty-2
dc.subjectVertebrates
dc.subjectMechanisms
dc.titleThe activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2347
oaire.citation.issue19
oaire.citation.startPage2342
oaire.citation.titleGenes & Development
oaire.citation.volume18
person.familyNameMarques
person.familyNameBorges
person.familyNameBelo
person.givenNameSara
person.givenNameAna
person.givenNameJosé A.
person.identifier.ciencia-idBB17-0F5D-A4FB
person.identifier.ciencia-idBF13-08E9-25E6
person.identifier.orcid0000-0001-6784-5612
person.identifier.orcid0000-0002-2572-6823
person.identifier.orcid0000-0001-7384-0949
person.identifier.ridF-4444-2012
person.identifier.scopus-author-id57190066063
person.identifier.scopus-author-id6602141392
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication20dd7142-5b7a-465f-8943-a6ac33b91df1
relation.isAuthorOfPublication48352462-c3d8-4d19-bf45-efc075a6074d
relation.isAuthorOfPublication4bebeb48-6fac-41a9-8363-f849def5e019
relation.isAuthorOfPublication.latestForDiscovery4bebeb48-6fac-41a9-8363-f849def5e019

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