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Tight regulation of unstructured proteins: from transcript synthesis to protein degradation

2008-11Journal article Open access
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dc.contributor.authorGsponer, Jorg
dc.contributor.authorFutschik, Matthias E.
dc.contributor.authorTeichmann, Sarah A.
dc.contributor.authorBabu, M. Madan
dc.date.accessioned2018-12-07T14:58:00Z
dc.date.available2018-12-07T14:58:00Z
dc.date.issued2008-11
dc.description.abstractAltered abundance of several intrinsically unstructured proteins ( IUPs) has been associated with perturbed cellular signaling that may lead to pathological conditions such as cancer. Therefore, it is important to understand how cells precisely regulate the availability of IUPs. We observed that regulation of transcript clearance, proteolytic degradation, and translational rate contribute to controlling the abundance of IUPs, some of which are present in low amounts and for short periods of time. Abundant phosphorylation and low stochasticity in transcription and translation indicate that the availability of IUPs can be finely tuned. Fidelity in signaling may require that most IUPs be available in appropriate amounts and not present longer than needed.
dc.description.sponsorshipRoyal Society; MRC Special Training Fellowship; Medical Research Council [MC_U105161047, MC_U105185859, G0600158]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1126/science.1163581
dc.identifier.issn0036-8075
dc.identifier.urihttp://hdl.handle.net/10400.1/11807
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Association for the Advancement of Science
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectIntrinsic disorder
dc.subjectAlpha-synuclein
dc.subjectCancer
dc.subjectPhosphorylation
dc.subjectMetabolism
dc.subjectProteasome
dc.subjectP27(Kip1)
dc.subjectDisease
dc.subjectBinding
dc.subjectP27
dc.titleTight regulation of unstructured proteins: from transcript synthesis to protein degradation
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1368
oaire.citation.issue5906
oaire.citation.startPage1365
oaire.citation.titleScience
oaire.citation.volume322
person.familyNameFutschik
person.givenNameMatthias
person.identifier.ciencia-idA71B-AD01-3501
person.identifier.orcid0000-0002-6245-8071
person.identifier.scopus-author-id14017989400
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationd58f3269-c7e1-4c22-b094-5cfe6750821b
relation.isAuthorOfPublication.latestForDiscoveryd58f3269-c7e1-4c22-b094-5cfe6750821b

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