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Cutaneous soft tissue sarcomas: survival-related factors

2021-07Journal article Restricted access
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dc.contributor.authorGkantaifi, Areti
dc.contributor.authorDiamantis, Alexandros
dc.contributor.authorMauri, Davide
dc.contributor.authorNixon, Ioanna
dc.contributor.authorKyriazoglou, Anastassios
dc.contributor.authorBaloyiannis, Ioannis
dc.contributor.authorTsoukalas, Nikolaos
dc.contributor.authorCharalampakis, Nikolaos
dc.contributor.authorSchizas, Dimitrios
dc.contributor.authorCuccia, Francesco
dc.contributor.authorAlongi, Filippo
dc.contributor.authorDe Mello, Ramon Andrade
dc.contributor.authorIliadis, George
dc.contributor.authorKamposioras, Konstantinos
dc.contributor.authorMazonakis, Michalis
dc.contributor.authorTolia, Maria
dc.date.accessioned2023-03-09T15:23:46Z
dc.date.available2023-03-09T15:23:46Z
dc.date.issued2021-07
dc.description.abstractCutaneous sarcomas are a heterogeneous group of rare mesenchymal neoplasms representing less than 1% of malignant tumors. Histology report remains the cornerstone for the diagnosis of these tumors. The most important clinicopathologic parameters related to prognosis include larger tumor size, high mitotic index, head and neck location, p53 mutations, depth of infiltration and histological grade, vascular and perineural invasion as well as the surgical margins status. Applying advanced biopsy techniques might offer more precise assessment of surgical margins, which constitutes a significant precondition for the management of these tumors. The management of cutaneous soft tissue sarcomas requires a multidisciplinary approach. Surgery remains the standard treatment, nonetheless adjuvant therapy may be required, consisting of radiotherapy, chemotherapy, and molecular targeted therapies to improve treatment outcomes. The role of molecular profiling in the treatment of uncontrolled disease is promising, but it may be offered to a relatively small proportion of patients and its use is still considered experimental in this setting. Due to the rarity of the disease, there is a need for knowledge and experience to be shared, pooled, organized and rationalized so that recent developments in medical science can have a major impact on the disease course. Multicenter clinical trials are needed to improve the care of patients with cutaneous sarcomas.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s00403-021-02268-1pt_PT
dc.identifier.eissn1432-069X
dc.identifier.urihttp://hdl.handle.net/10400.1/19214
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectCutaneouspt_PT
dc.subjectSarcomaspt_PT
dc.subjectFactorspt_PT
dc.subjectBiopsypt_PT
dc.subjectTreatmentpt_PT
dc.subjectSurvivalpt_PT
dc.subjectRecurrencept_PT
dc.titleCutaneous soft tissue sarcomas: survival-related factorspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage631pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage625pt_PT
oaire.citation.titleArchives of Dermatological Researchpt_PT
oaire.citation.volume314pt_PT
person.familyNamede Mello
person.givenNameRamon Andrade
person.identifier.orcid0000-0002-9640-4573
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication53ee625f-c5c3-468b-85bb-4cef5ad36928
relation.isAuthorOfPublication.latestForDiscovery53ee625f-c5c3-468b-85bb-4cef5ad36928

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