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Assessing medication use patterns by clinical outcomes severity among inpatients with COVID-19: a retrospective drug utilization study

2024Journal article Open access
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dc.contributor.authorFerreira-da-Silva, Renato
dc.contributor.authorMaranhão, Priscila
dc.contributor.authorDias, Cláudia Camila
dc.contributor.authorAlves, João Miguel
dc.contributor.authorPires, Ligia
dc.contributor.authorMorato, Manuela
dc.contributor.authorPolónia, Jorge Junqueira
dc.contributor.authorRibeiro-Vaz, Inês
dc.date.accessioned2024-04-09T10:37:39Z
dc.date.available2024-04-09T10:37:39Z
dc.date.issued2024
dc.description.abstractPurpose: This study assessed medication patterns for inpatients at a central hospital in Portugal and explored their relationships with clinical outcomes in COVID-19 cases. Methods: A retrospective study analyzed inpatient medication data, coded using the Anatomical Therapeutic Chemical classification system, from electronic patient records. It investigated the association between medications and clinical severity outcomes such as ICU admissions, respiratory/circulatory support needs, and hospital discharge status, including mortality (identified by ICD-10-CM/PCS codes). Multivariate analyses incorporating demographic data and comorbidities were used to adjust for potential confounders and understand the impact of medication patterns on disease progression and outcomes. Results: The analysis of 2688 hospitalized COVID-19 patients (55.3% male, average age 62.8 years) revealed a significant correlation between medication types and intensity and disease severity. Cases requiring ICU admission or ECMO support often involved blood and blood-forming organ drugs. Increased use of nervous system and genitourinary hormones was observed in nonsurvivors. Corticosteroids, like dexamethasone, were common in critically ill patients, while tocilizumab was used in ECMO cases. Medications for the alimentary tract, metabolism, and cardiovascular system, although widely prescribed, were linked to more severe cases. Invasive mechanical ventilation correlated with higher usage of systemic anti-infectives and musculoskeletal medications. Trends in co-prescribing blood-forming drugs with those for acid-related disorders, analgesics, and antibacterials were associated with intensive interventions and worse outcomes. Conclusions: The study highlights complex medication regimens in managing severe COVID-19, underscoring specific drug patterns associated with critical health outcomes. Further research is needed to explore these patterns.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.biopha.2024.116242pt_PT
dc.identifier.issn0753-3322
dc.identifier.urihttp://hdl.handle.net/10400.1/20618
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCenter for Health Technology and Services Research
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectDrug utilizationpt_PT
dc.subjectDrug prescriptionspt_PT
dc.subjectRetrospective studiespt_PT
dc.subjectPharmacotherapypt_PT
dc.titleAssessing medication use patterns by clinical outcomes severity among inpatients with COVID-19: a retrospective drug utilization studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Health Technology and Services Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04255%2F2020/PT
oaire.citation.startPage116242pt_PT
oaire.citation.titleBiomedicine & Pharmacotherapypt_PT
oaire.citation.volume172pt_PT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication1493be4c-cc8c-4a5d-a302-2ae598dcfe84
relation.isProjectOfPublication.latestForDiscovery1493be4c-cc8c-4a5d-a302-2ae598dcfe84

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