Repository logo
 
Publication

Blood biomarkers to detect functional impairment in adult patients with repaired tetralogy of Fallot

2023Journal article Open access
Simple item page
dc.contributor.authorAlborikan, S.
dc.contributor.authorAlthunayyan, A.
dc.contributor.authorPandya, B.
dc.contributor.authorVon Klemperer, K.
dc.contributor.authorWalker, F.
dc.contributor.authorCullen, S.
dc.contributor.authorBhan, A.
dc.contributor.authorBadiani, S.
dc.contributor.authorEncarnacion, D.
dc.contributor.authorMonteiro, Regina
dc.contributor.authorPetersen, S.E.
dc.contributor.authorBhattacharyya, S.
dc.contributor.authorLloyd, G.
dc.date.accessioned2024-01-18T10:40:09Z
dc.date.available2024-01-18T10:40:09Z
dc.date.issued2023
dc.description.abstractBackground: The relationship between plasma brain natriuretic peptide (NT-proBNP) and soluble suppression of tumorigenicity-2 (sST2) with structural adaptions and exercise capacity remains incompletely described in patients with repaired Tetralogy of Fallot (rTOF).Methods: Peripheral venous blood samples were drawn for 99 patients with repaired TOF, 59 patients with severe pulmonary regurgitation (PR) and 40 patients with no or mild PR. NT-proBNP was measured using enzyme-linked immunosorbent assays (Roche Diagnostics, Indianapolis, IN). Soluble ST2 levels were assessed on Aspect-plus ST2 quantitative rapid test.Results: The mean value of NT-proBNP was 160 +/- 137 pg/ml, and sST2 was 29 +/- 13, ng/ml in the entire population. 58 % had an elevated NT-proBNP, while sST2 was abnormal in 40 %. Mean NT-proBNP was significantly higher in patients with severe PR (169 +/- 150 vs145 +/- 118, pg/ml, p < 0.001), while similar sST2 levels were observed in both groups (29 +/- 14 vs30 +/- 12, ng/ml, p > 0.05). NT-proBNP and sST2 levels were higher in patients with transannular patch when compared to other RVOT intervention (174 +/- 145 vs 107 +/- 100, pg/ml, p < 0.001); (31 +/- 13 vs 29 +/- 15, ng/ml, p < 0.05). Both biomarkers were significantly associated with exercise capacity, but NT-proBNP (r =-0.60, p < 0.001) was stronger. The optimal cut-off of 90 pg/ml for NT-proBNP had a sensitivity of 74 % and specificity of 63 % for detection of impaired exercise capacity.Conclusions: Serum levels of sST2 and NT-proBNP are elevated in patients with repaired TOF, with higher values observed in those with severe PR, but also in patients undergoing transannular patch repair. Incorporating both markers in these patients increased the ability to detect impairment in exercise capacity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijcchd.2023.100483pt_PT
dc.identifier.issn2666-6685
dc.identifier.urihttp://hdl.handle.net/10400.1/20310
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBrain natriuretic peptidept_PT
dc.subjectRight-ventricular volumespt_PT
dc.subjectChronic heart-failurept_PT
dc.subjectExercise capacitypt_PT
dc.subject3-dimensional echocardiographypt_PT
dc.subjectEjection fractionpt_PT
dc.subjectReference valuespt_PT
dc.subjectSurgical repairpt_PT
dc.subjectSoluble st2pt_PT
dc.subjectGuidelinespt_PT
dc.titleBlood biomarkers to detect functional impairment in adult patients with repaired tetralogy of Fallotpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage100483pt_PT
oaire.citation.titleInternational Journal of Cardiology Congenital Heart Diseasept_PT
oaire.citation.volume14pt_PT
person.familyNameMonteiro
person.givenNameRegina
person.identifier.orcid0000-0002-9394-7919
person.identifier.scopus-author-id7102451353
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione12eaf5b-9414-4311-95af-b629e61e00fb
relation.isAuthorOfPublication.latestForDiscoverye12eaf5b-9414-4311-95af-b629e61e00fb

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S2666668523000459-main.pdf
Size:
1.79 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.46 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)