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Performance of the Bethesda system for reporting thyroid cytology in multi-institutional large cohort of pediatric thyroid nodules: a detailed analysis

2022-01-12Journal article Open access
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dc.contributor.authorCanberk, Sule
dc.contributor.authorBarroca, Helena
dc.contributor.authorGirão, Inês
dc.contributor.authorAydın, Ozlem
dc.contributor.authorUguz, Aysun
dc.contributor.authorErdogan, Kıvılcım
dc.contributor.authorTastekin, Ebru
dc.contributor.authorBongiovanni, Massimo
dc.contributor.authorSoares, Paula
dc.contributor.authorMáximo, Valdemar
dc.contributor.authorSchmitt, Fernando
dc.date.accessioned2022-02-09T09:54:55Z
dc.date.available2022-02-09T09:54:55Z
dc.date.issued2022-01-12
dc.date.updated2022-01-20T15:24:22Z
dc.description.abstractBackground: To evaluate the performance of TBSRTC through multi-institutional experience in the paediatric population and questioning the management recommendation of ATA Guidelines Task Force on Paediatric Thyroid Cancer; Methods: A retrospective search was conducted in 4 institutions to identify consecutive thyroid FNAC cases in paediatric population between 2000 and 2018. Following the 2nd TBSRTC, the risk of malignancy ratios (ROMs) was given in ranges and calculated by 2 different ways. Sensitivity, specificity, PPV, NPV and DA ratios were calculated using histologic diagnosis as the gold standard; Results: Among a total of 405 specimens, the distribution of cases for each category was, 44 (11%) for ND, 204 (50%) for B category, 40 (10%) for AUS/FLUS, 36 (9%) for FN/SFN, 24 (6%) for SFM and 57 (14%) for M categories. 153 cases have a histological diagnosis. The ratio of surgery was 23% in ND, 16% in the B, 45% for AUS/FLUS, 75% for SFN/FN and 92% for SFM and 75% in M categories; Conclusions: The data underlines the high ROM values in paediatric population which might be clinically meaningful. The high rate of malignancy of the cohort of operated patients (50%) also underlines the need of better preoperative indicators for stratification. Considering that more than half of the nodules in AUS/FLUS category were benign, direct surgery recommendation could be questionable as proposed in ATA 2015 guidelines.pt_PT
dc.description.sponsorshipNORTE-01-0145-FEDER-000051
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifierdoi: 10.3390/diagnostics12010179
dc.identifier.citationDiagnostics 12 (1): 179 (2022)pt_PT
dc.identifier.doi10.3390/diagnostics12010179pt_PT
dc.identifier.issn2075-4418
dc.identifier.urihttp://hdl.handle.net/10400.1/17534
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationDIABETES MELLITUS AND ONCOCYTIC TUMORS OF THYROID: THE MITOCHONDRIAL CONNECTION
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPaediatric thyroid nodulespt_PT
dc.subjectThe Bethesda system for reporting thyroid cytologypt_PT
dc.subjectThyroid cytologypt_PT
dc.subjectTBSRTCpt_PT
dc.subjectPaediatric cytologypt_PT
dc.subjectFNACpt_PT
dc.subjectBethesda systempt_PT
dc.titlePerformance of the Bethesda system for reporting thyroid cytology in multi-institutional large cohort of pediatric thyroid nodules: a detailed analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDIABETES MELLITUS AND ONCOCYTIC TUMORS OF THYROID: THE MITOCHONDRIAL CONNECTION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F147650%2F2019/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage179pt_PT
oaire.citation.titleDiagnosticspt_PT
oaire.citation.volume12pt_PT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationf3eeb95e-819f-47ef-aa6e-acbb0148fa52
relation.isProjectOfPublication.latestForDiscoveryf3eeb95e-819f-47ef-aa6e-acbb0148fa52

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