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Long‐term association between disease activity and disability in early axial Spondyloarthritis: Results from a prospective observational study of inflammatory back pain

dc.contributor.authorPD, Carvalho
dc.contributor.authorRuyssen‐Witrand, Adeline
dc.contributor.authorMarreiros, Ana
dc.contributor.authorMachado, Pedro M.
dc.date.accessioned2022-06-09T09:20:53Z
dc.date.available2022-06-09T09:20:53Z
dc.date.issued2022
dc.description.abstractObjective Our primary objective was to study the long-term association between disease activity and disability in axial spondyloarthritis (SpA). Our secondary objective was to define patient profiles according to their level of disability. Methods We analyzed data collected during the first 5 years of follow-up of a large early axial SpA cohort, the Devenir des Spondylarthropathies Indifferenciees Recentes (DESIR) cohort. Multivariable models were built to study the association between the Health Assessment Questionnaire for Ankylosing Spondylitis (HAQ-AS) and the Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP), adjusting for potential confounders. Hierarchical multivariable analysis was conducted using the chi-square automatic interaction detector (CHAID) method, to help determine how variables best cluster to explain HAQ-AS. Results Data from 644 patients and 5,152 visits were analyzed. HAQ-AS was longitudinally, independently, and positively associated with ASDAS-CRP (adjusted B [adjB] 0.205 [95% confidence interval (95% CI) 0.187, 0.222]), the enthesitis score (adjB 0.011 [95% CI 0.008, 0.015]), the Bath Ankylosing Spondylitis Metrology Index (adjB 0.087 [95% CI 0.069, 0.105]), and female sex (adjB 0.172 [95% CI 0.120, 0.225]). The CHAID decision tree revealed ASDAS-CRP as the first variable with discriminative power on HAQ-AS. The cutoffs that separated different patient disability profiles were obtained. Conclusion Disease activity contributes longitudinally to disability and is hierarchically superior to any other variable in explaining this health domain. Enthesitis and spinal mobility are also key drivers of disability in early axial SpA. ASDAS-CRP cutoffs that separated different patient disability profiles largely mimicked the cutoffs previously defined for ASDAS-CRP disease activity states.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/acr.24515pt_PT
dc.identifier.issn2151-464X
dc.identifier.urihttp://hdl.handle.net/10400.1/17848
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectQuallity-of-lifept_PT
dc.subjectActivity score asdaspt_PT
dc.subjectAnkylosing-spondylitispt_PT
dc.subjectFunctional statuspt_PT
dc.titleLong‐term association between disease activity and disability in early axial Spondyloarthritis: Results from a prospective observational study of inflammatory back painpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage775pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage768pt_PT
oaire.citation.titleArthritis Care & Researchpt_PT
oaire.citation.volume74pt_PT
person.familyNameCarvalho
person.familyNameMarreiros
person.givenNamePedro David
person.givenNameAna
person.identifier.ciencia-id9A12-9450-7051
person.identifier.orcid0000-0001-8255-4274
person.identifier.orcid0000-0001-9410-4772
person.identifier.ridI-4379-2016
person.identifier.scopus-author-id57194785077
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8695cb83-0deb-4735-82b2-6f0cc3f2d085
relation.isAuthorOfPublicationc0a8e5da-26ae-42a8-ab04-fa4df4356375
relation.isAuthorOfPublication.latestForDiscoveryc0a8e5da-26ae-42a8-ab04-fa4df4356375

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