Repository logo
 
Publication

Measuring quality of life of patients with axial spondyloarthritis for economic evaluation

2022Journal article Open access
Simple item page
dc.contributor.authorHernandez Alava, Monica
dc.contributor.authorWailoo, Allan
dc.contributor.authorChrysanthou, Georgios
dc.contributor.authorBarcelos, Filipe
dc.contributor.authorvan Gaalen, Floris A
dc.contributor.authorSantos, Helena
dc.contributor.authorFagerli, Karen Minde
dc.contributor.authorGago, Laura
dc.contributor.authorMargarida Cunha, Maria
dc.contributor.authorvan de Sande, Marleen
dc.contributor.authorCouto, Maura C
dc.contributor.authorBernardes, Miguel
dc.contributor.authorRamonda, Roberta
dc.contributor.authorExarchou, Sofia
dc.contributor.authorPD, Carvalho
dc.contributor.authorvan der Heijde, Desirée
dc.contributor.authorMachado, Pedro M
dc.date.accessioned2022-04-19T13:21:19Z
dc.date.available2022-04-19T13:21:19Z
dc.date.issued2022
dc.description.abstractObjectives To estimate the relationship between EQ5D (three levels, UK version) and the Ankylosing Spondylitis Disease Activity Score (ASDAS) for use in the economic evaluation of health technologies for people with axial spondyloarthritis (axSpA). To compare against the relationship with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Methods An electronic, prospective, Portuguese, nationwide, rheumatic disease register (Reuma.pt) provided data on 1140 patients (5483 observations) with a confirmed diagnosis of axSpA. We estimated models of EQ5D as a function of ASDAS, alone or in combination with measures of functional impairment, using bespoke mixture models which reflect the complex distributional features of EQ5D. The SPondyloArthritis Caught Early cohort provided data from 344 patients (1405 observations) in four European countries and was used for validation. A previously published model of BASDAI/Bath Ankylosing Spondylitis Functional Index (BASFI) was also used to generate predicted EQ5D scores and model performance compared. Results A non-linear relationship exists between EQ5D from ASDAS. The final model included ASDAS, ASDAS squared, age and age squared and demonstrated close fit in both datasets except where data were sparse for patients with very high levels of disease activity (ASDAS >4). This finding held in the validation dataset. Models that included BASFI improved model fit. The ASDAS based models fit the data marginally less well than models using BASDAI. Conclusions Mapping models linking ASDAS to EQ5D allow results from clinical studies to be used in economic evaluation of health technologies with confidence. There is some loss of information compared with BASDAI but this has only a marginal impact.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1136/rmdopen-2021-001955pt_PT
dc.identifier.issn2056-5933
dc.identifier.urihttp://hdl.handle.net/10400.1/17770
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEconomicspt_PT
dc.subjectPatient reported outcome measurespt_PT
dc.subjectSpondylitispt_PT
dc.subjectAnkylosingpt_PT
dc.titleMeasuring quality of life of patients with axial spondyloarthritis for economic evaluationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPagee001955pt_PT
oaire.citation.titleRMD Openpt_PT
oaire.citation.volume8pt_PT
person.familyNameCarvalho
person.givenNamePedro David
person.identifier.orcid0000-0001-8255-4274
person.identifier.ridI-4379-2016
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8695cb83-0deb-4735-82b2-6f0cc3f2d085
relation.isAuthorOfPublication.latestForDiscovery8695cb83-0deb-4735-82b2-6f0cc3f2d085

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
e001955.full.pdf
Size:
438.01 KB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)