Repository logo
 
Publication

Analysis of the clinical relevance of histological classification of benign epithelial salivary gland tumours

2019-06Journal article Open access
Simple item page
dc.contributor.authorHellquist, Henrik
dc.contributor.authorPaiva-Correia, António
dc.contributor.authorPoorten, Vincent Vander
dc.contributor.authorQuer, Miquel
dc.contributor.authorHernandez-Prera, Juan C.
dc.contributor.authorAndreasen, Simon
dc.contributor.authorZbären, Peter
dc.contributor.authorSkalova, Alena
dc.contributor.authorRinaldo, Alessandra
dc.contributor.authorFerlito, Alfio
dc.date.accessioned2019-08-30T11:29:22Z
dc.date.available2019-08-30T11:29:22Z
dc.date.issued2019-06
dc.description.abstractIntroductionA vast increase in knowledge of numerous aspects of malignant salivary gland tumours has emerged during the last decade and, forseveral reasons, thishas not been the case in benign epithelial salivary gland tumours. We have performed a literature review to investigate whether an accurate histological diagnosis of the 11 different types of benign epithelial salivary gland tumours is correlated to any differences in their clinical behaviour.MethodsA search was performed for histological classifications, recurrence rates and risks for malignant transformation, treatment modalities, and prognosis of these tumours. The search was performed primarily through PubMed, Google Scholar, and all versions of WHO classifications since 1972, as well as numerous textbooks on salivary gland tumours/head and neck/pathology/oncology. A large number of archival salivary tumours were also reviewed histologically.ResultsPleomorphic adenomas carry a considerable risk (5-15%) for malignant transformation but, albeit to a much lesser degree, so do basal cell adenomas and Warthin tumours, while the other eight types virtually never develop into malignancy. Pleomorphic adenoma has a rather high risk for recurrence while recurrence occurs only occasionally in sialadenoma papilliferum, oncocytoma, canalicular adenoma, myoepithelioma and the membranous type of basal cell adenoma. Papillomas, lymphadenoma, sebaceous adenoma, cystadenoma, basal cell adenoma (solid, trabecular and tubular subtypes) very rarely, if ever, recur.ConclusionsA correct histopathological diagnosis of these tumours is necessary due to (1) preventing confusion with malignant salivary gland tumours; (2) only one (pleomorphic adenoma) has a considerable risk for malignant transformation, but all four histological types ofbasal cell adenoma canoccasionally develop into malignancy, as does Warthin tumour; (3) sialadenoma papilliferum, oncocytoma, canalicular adenoma, myoepithelioma and Warthin tumour only occasionally recur; while (4) intraductal and inverted papilloma, lymphadenoma, sebaceous adenoma, cystadenoma, basal cell adenoma (apart from the membranous type) virtually never recur. No biomarker was found to be relevant for predicting recurrence or potential malignant development. Guidelines for appropriate treatment strategies are given.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1007/s12325-019-01007-3
dc.identifier.issn0741-238X
dc.identifier.urihttp://hdl.handle.net/10400.1/12747
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs12325-019-01007-3pt_PT
dc.subjectBenign salivary gland tumourspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectMalignant transformationpt_PT
dc.subjectPubMedpt_PT
dc.subjectRecurrencept_PT
dc.subjectSalivary gland neoplasmspt_PT
dc.subjectTreatment modalitiespt_PT
dc.titleAnalysis of the clinical relevance of histological classification of benign epithelial salivary gland tumourspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1974pt_PT
oaire.citation.startPage1950pt_PT
oaire.citation.titleAdvances in Therapypt_PT
oaire.citation.volume36pt_PT
person.familyNameHellquist
person.familyNameQuer
person.givenNameHenrik
person.givenNameMiquel
person.identifier.ciencia-id9C11-221B-93BF
person.identifier.orcid0000-0003-3044-6065
person.identifier.orcid0000-0003-2563-6729
person.identifier.scopus-author-id7003550744
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione632b82a-cf09-4f9a-b445-9d9a9de47438
relation.isAuthorOfPublication61c6c459-b57e-479c-a9d9-937c938a3029
relation.isAuthorOfPublication.latestForDiscoverye632b82a-cf09-4f9a-b445-9d9a9de47438

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours .pdf
Size:
1.75 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.46 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)