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Combining gamma with Alpha and Beta power modulation for enhanced cortical mapping in patients with focal epilepsy

2020Journal article Open access
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dc.contributor.authorArchila-Meléndez, Mario E.
dc.contributor.authorValente, Giancarlo
dc.contributor.authorGommer, Erik D.
dc.contributor.authorCorreia, João
dc.contributor.authorten Oever, Sanne
dc.contributor.authorPeters, Judith C.
dc.contributor.authorReithler, Joel
dc.contributor.authorHendriks, Marc P. H.
dc.contributor.authorCornejo Ochoa, William
dc.contributor.authorSchijns, Olaf E. M. G.
dc.contributor.authorDings, Jim T. A.
dc.contributor.authorHilkman, Danny M. W.
dc.contributor.authorRouhl, Rob P. W.
dc.contributor.authorJansma, Bernadette M.
dc.contributor.authorvan Kranen-Mastenbroek, Vivianne H. J. M.
dc.contributor.authorRoberts, Mark J.
dc.date.accessioned2021-01-27T14:33:39Z
dc.date.available2021-01-27T14:33:39Z
dc.date.issued2020
dc.description.abstractAbout one third of patients with epilepsy have seizures refractory to the medical treatment. Electrical stimulation mapping (ESM) is the gold standard for the identification of "eloquent" areas prior to resection of epileptogenic tissue. However, it is time-consuming and may cause undesired side effects. Broadband gamma activity (55-200 Hz) recorded with extraoperative electrocorticography (ECoG) during cognitive tasks may be an alternative to ESM but until now has not proven of definitive clinical value. Considering their role in cognition, the alpha (8-12 Hz) and beta (15-25 Hz) bands could further improve the identification of eloquent cortex. We compared gamma, alpha and beta activity, and their combinations for the identification of eloquent cortical areas defined by ESM. Ten patients with intractable focal epilepsy (age: 35.9 ± 9.1 years, range: 22-48, 8 females, 9 right handed) participated in a delayed-match-to-sample task, where syllable sounds were compared to visually presented letters. We used a generalized linear model (GLM) approach to find the optimal weighting of each band for predicting ESM-defined categories and estimated the diagnostic ability by calculating the area under the receiver operating characteristic (ROC) curve. Gamma activity increased more in eloquent than in non-eloquent areas, whereas alpha and beta power decreased more in eloquent areas. Diagnostic ability of each band was close to 0.7 for all bands but depended on multiple factors including the time period of the cognitive task, the location of the electrodes and the patient's degree of attention to the stimulus. We show that diagnostic ability can be increased by 3-5% by combining gamma and alpha and by 7.5-11% when gamma and beta were combined. We then show how ECoG power modulation from cognitive testing can be used to map the probability of eloquence in individual patients and how this probability map can be used in clinical settings to optimize ESM planning. We conclude that the combination of gamma and beta power modulation during cognitive testing can contribute to the identification of eloquent areas prior to ESM in patients with refractory focal epilepsy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fnhum.2020.555054pt_PT
dc.identifier.issn1662-5161
dc.identifier.urihttp://hdl.handle.net/10400.1/14989
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectElectrocorticography-based functional mappingpt_PT
dc.subjectFrequencybased cortical mappingpt_PT
dc.subjectElectrical stimulation mappingpt_PT
dc.subjectBroadband gamma frequencypt_PT
dc.subjectAlpha frequency bandpt_PT
dc.subjectBeta frequency bandpt_PT
dc.subjectDrug-resistant epilepsypt_PT
dc.subjectEpilepsy surgerypt_PT
dc.titleCombining gamma with Alpha and Beta power modulation for enhanced cortical mapping in patients with focal epilepsypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage555054pt_PT
oaire.citation.titleFrontiers in Human Neurosciencept_PT
oaire.citation.volume14pt_PT
person.familyNameCorreia
person.givenNameJoao
person.identifier.ciencia-id6417-495C-B044
person.identifier.orcid0000-0001-6624-7012
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationaf3ec6e1-51fb-4aa8-8c57-54cb3056f45d
relation.isAuthorOfPublication.latestForDiscoveryaf3ec6e1-51fb-4aa8-8c57-54cb3056f45d

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